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Biological Trace Element Research

, Volume 131, Issue 2, pp 133–142 | Cite as

Chromium Improves Glucose Uptake and Metabolism Through Upregulating the mRNA Levels of IR, GLUT4, GS, and UCP3 in Skeletal Muscle Cells

  • Wei Qiao
  • Zhongli Peng
  • Zhisheng Wang
  • Jing Wei
  • Anguo ZhouEmail author
Article

Abstract

The aim of this study was to evaluate the impact of three different chromium forms as chromic chloride (CrCl), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP) on glucose uptake and metabolism in vitro. In cultured skeletal muscle cells, chromium augmented insulin-stimulated glucose uptake and metabolism as assessed by a reduced glucose concentration of culture medium. At the molecular level, insulin significantly increased the mRNA levels of insulin receptor (IR), glucose transporter 4 (GLUT4), glycogen synthase (GS), and uncoupling protein-3 (UCP3), and these impacts can be enhanced by the addition of chromium, especially in the form of CrSP. Collectively, results of this study demonstrate that chromium improves glucose uptake and metabolism through upregulating the mRNA levels of IR, GLUT4, GS, and UCP3 in skeletal muscle cells, and CrSP has higher efficacy on glucose uptake and metabolism compared to the forms of CrCl and CrPic.

Keywords

Chromium Insulin Glucose uptake Glucose metabolism Insulin receptor Glucose transporter 4 Glycogen synthase Uncoupling protein-3 

Notes

Acknowledgments

This article was financially supported by the Program for Changjiang Scholars and Innovative Research Team in University, China, IRTO555.

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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Wei Qiao
    • 1
  • Zhongli Peng
    • 2
  • Zhisheng Wang
    • 1
  • Jing Wei
    • 3
  • Anguo Zhou
    • 1
    Email author
  1. 1.Engineering Research Center of Animal Disease-Resistance Nutrition of ChinaMinistry of EducationYa’anChina
  2. 2.Southwest University for NationalitiesChengduChina
  3. 3.The second Station for Feed Quality Monitoring and Inspection of Sichuan ProvinceChengduChina

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