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Evaluation of Oxidative Stress, Antioxidant Status and Serum Vitamin C Levels in Cancer Patients

  • Reza MahdaviEmail author
  • Elnaz FaramarziEmail author
  • Ensiyeh Seyedrezazadeh
  • Mohammad Mohammad-zadeh
  • Masoud Pourmoghaddam
Article

Abstract

Taking into account the importance role of lipid peroxidation and antioxidants in the prevention and incidence of cancer, the present study was carried out to determine oxidative stress, serum total antioxidant (TAS), and vitamin C levels in cancer patients. Malondialdehyde(MDA), total antioxidant status, and vitamin C levels of 57cancer patients aged 19–80 years and 22 healthy subjects (control group) aged 22–76 years were evaluated. Serum concentrations of MDA as thiobarbitaric acid complexes were measured by fluorometry method, the serum TAS by using commercial test kits from Randox Laboratories, and vitamin C by using spectrocolorimetric method. The mean serum MDA concentrations of all cancer groups except lung cancer were significantly higher than control group (P < 0.004). The mean total antioxidant status was insignificantly higher than control group. The mean serum vitamin C level was significantly lower in patients as compared to the healthy subjects (PV < 0.0001). In conclusion, an alteration in the lipid peroxidation with concomitant changes in antioxidant defense system in cancer patients may be due to excessive oxidative stress. Serum low levels of vitamin C in the different type of cancer patients in spite of adequate daily intake may be due to increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells.

Keywords

Cancer Serum malondialdehyde Total antioxidant status Vitamin C 

Notes

Acknowledgments

Financial support of Tabriz University of Medical Sciences is gratefully acknowledged.

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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Reza Mahdavi
    • 1
    Email author
  • Elnaz Faramarzi
    • 1
    • 5
    Email author
  • Ensiyeh Seyedrezazadeh
    • 2
  • Mohammad Mohammad-zadeh
    • 3
  • Masoud Pourmoghaddam
    • 4
  1. 1.Nutritional Research CenterTabriz University of Medical SciencesTabrizIran
  2. 2.School of Public Health and NutritionTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Radiotherapy Imam Khomeini HospitalTabriz University of Medical SciencesTabrizIran
  4. 4.Faculty of MedicineTabriz University of Medical SciencesTabrizIran
  5. 5.Department of Nutrition, School of Public Health and NutritionTabriz University Medical SciencesTabrizIran

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