Evaluation of Oxidative Stress, Antioxidant Status and Serum Vitamin C Levels in Cancer Patients
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Taking into account the importance role of lipid peroxidation and antioxidants in the prevention and incidence of cancer, the present study was carried out to determine oxidative stress, serum total antioxidant (TAS), and vitamin C levels in cancer patients. Malondialdehyde(MDA), total antioxidant status, and vitamin C levels of 57cancer patients aged 19–80 years and 22 healthy subjects (control group) aged 22–76 years were evaluated. Serum concentrations of MDA as thiobarbitaric acid complexes were measured by fluorometry method, the serum TAS by using commercial test kits from Randox Laboratories, and vitamin C by using spectrocolorimetric method. The mean serum MDA concentrations of all cancer groups except lung cancer were significantly higher than control group (P < 0.004). The mean total antioxidant status was insignificantly higher than control group. The mean serum vitamin C level was significantly lower in patients as compared to the healthy subjects (PV < 0.0001). In conclusion, an alteration in the lipid peroxidation with concomitant changes in antioxidant defense system in cancer patients may be due to excessive oxidative stress. Serum low levels of vitamin C in the different type of cancer patients in spite of adequate daily intake may be due to increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells.
KeywordsCancer Serum malondialdehyde Total antioxidant status Vitamin C
Financial support of Tabriz University of Medical Sciences is gratefully acknowledged.
- 8.Das UN (2002) A radical approach to cancer. Med Sci Monit 8:79–92Google Scholar
- 10.World Cancer Research Fund/American Institute for Cancer Research (1997) Food research and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington, DCGoogle Scholar
- 13.Burtis CA, Ashwood ER (1999) Tietz textbook of clinical chemistry. Saunders, PhiladelphiaGoogle Scholar
- 14.Clancy KJ, Davidson NJ (2000) The biology of breast carcinoma. Cancer 97:825–833Google Scholar
- 15.Rushmore TH, Morton MR, Pickett CB (1992) The antioxidant response element. J Biol Chem 66:11632–11639Google Scholar
- 24.Levine M, Katz A, Padayatty S (1999) Vitamin C. In: Shils ME, Olson JA, Shike M, Ross AC (eds) Modern nutrition in health and disease. Williams & Wilkins, Baltimore, pp 507–524Google Scholar