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Hepatoprotective Potentials of Onion and Garlic Extracts on Cadmium-Induced Oxidative Damage in Rats

  • Udoka E. ObiohaEmail author
  • Stephen M. Suru
  • Kikelomo F. Ola-Mudathir
  • Toyin Y. Faremi
Article

Abstract

The hepatoprotective effect of onion and garlic extracts on cadmium (Cd)-induced oxidative damage in rats is reported. Control group received double-distilled water alone. Cd group was challenged with 3CdSO4·8H2O (as Cd; 1.5 mg/kg bw per day per oral) alone, while extract-treated groups were pretreated with varied doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and thereafter co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks. Cd caused a marked (p < 0.001) increase in the levels of lipid peroxidation and glutathione S-transferase, whereas glutathione, superoxide dismutase, and catalase levels were decreased in the liver. We also observed a decrease in hepatic activities of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase and a concomitant increase in the plasma activities of ALT and AST. Onion and garlic extracts significantly attenuated these adverse effects of Cd. Onion extract proffered a dose-dependent hepatoprotection. Our study showed that Cd-induced oxidative damage in rat liver is amenable to attenuation by high dose of onion and moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity.

Keywords

Hepatoprotection Cadmium Onion Garlic Oxidative damage Antioxidant 

Notes

Acknowledgments

The authors gratefully acknowledged the Department of Biochemistry, University of Ibadan, Ibadan, Nigeria for providing the basic facilities used in this study.

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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Udoka E. Obioha
    • 1
    Email author
  • Stephen M. Suru
    • 1
  • Kikelomo F. Ola-Mudathir
    • 1
  • Toyin Y. Faremi
    • 1
  1. 1.Department of Biochemistry, Faculty of Basic Medical Sciences, College of MedicineUniversity of IbadanIbadanNigeria

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