Trace Element Levels in Hashimoto Thyroiditis Patients with Subclinical Hypothyroidism

  • Muhammed Erdal
  • Mustafa SahinEmail author
  • Adnan Hasimi
  • Gökhan Uckaya
  • Mustafa Kutlu
  • Kenan Saglam


The present study was conducted to evaluate the serum copper, zinc, magnesium, and selenium levels in patients with subclinical hypothyroidism in the iodine-rich region of Ankara, Turkey. The effects of hormone replacement therapy on these elements were also studied in these patients. Basal levels of selenium and iron in patients were significantly lower than control group (67.7 ± 10.4 vs. 83.7 ± 17.3 μg/dl, p = 0.02; 55.7 ± 38 vs 275.7 ± 24, P = 0.03 μg/dl). Serum magnesium levels were significantly higher in patient group (2.16 ± 0.31 vs 1.95 ± 0.13 mg/dl, P < 0.0001). There was a correlation between selenium levels with hsCRP (r = −0.408, p = 0.007). HsCRP levels in patients with selenium levels <80 μg/l (n = 31) was significantly higher than hsCRP levels in patients with selenium levels >80 μg/l (n = 12; 1.99 ± 1.0; 1.02 ± 0.9, p = 0.014). None of these biochemical risk factors and trace elements have changed after euthyroidism in patients with SH when compared to pretreatment levels. Selenium deficiency may contribute to cardiovascular disease risk in these patients.


Trace elements Subclinical hypothyroidism TSH 


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Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  • Muhammed Erdal
    • 1
  • Mustafa Sahin
    • 2
    • 4
    Email author
  • Adnan Hasimi
    • 3
  • Gökhan Uckaya
    • 2
  • Mustafa Kutlu
    • 2
  • Kenan Saglam
    • 1
  1. 1.Department of Family MedicineGulhane School of MedicineAnkaraTurkey
  2. 2.Department of Endocrinology and MetabolismGulhane School of MedicineAnkaraTurkey
  3. 3.Department of BiochemistryGulhane School of MedicineAnkaraTurkey
  4. 4.Endocrinology and Metabolism DepartmentGulhane University School of MedicineAnkaraTurkey

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