Biological Trace Element Research

, Volume 123, Issue 1–3, pp 191–201 | Cite as

Effects of High Levels of Dietary Silicon on Bone Development of Growing Rats and Turkeys Fed Semi-purified Diets



Two experiments were conducted using a completely randomized design to study the effects of high levels of silicon (Si) supplementation on bone development, structure, and strength in growing rats and turkeys. Rats were supplemented at two dietary Si levels: 0 and 500 ppm; and the turkeys were supplemented at four dietary Si levels: 0, 135, 270, and 540 ppm in semi-purified diets of dextrose-albumin for rats and dextrose-casein for turkeys. The experiments lasted 8 and 4 weeks for the rats and turkeys, respectively. Physical, mechanical, and chemical parameters of bones were measured. All the physical and mechanical measures of bone size and strength were not different (P > 0.05) between treatments in rats and turkeys except the moment of inertia, which was lower (P < 0.01) in rats on the 500 ppm Si level of supplementation. There were small but consistent reductions in structural and strength parameters with Si supplementation which were not wholly due to differences in bodyweights of the rats and turkeys. Although bone mineral composition was not affected (P > 0.05) by Si supplementation, plasma magnesium (P = 0.08) in rats and plasma calcium (P < 0.05) in turkeys were reduced by high levels of Si supplementation. The antagonistic relations of high Si levels with calcium and magnesium were deemed to be the mechanisms through which high Si imposes its deleterious effects on bone size and strength.


Silicon Bone Maximal stress Maximal load Elasticity Minerals Serum alkaline phosphatase 


  1. 1.
    Iler RK. The chemistry of silica. John Wiley and Sons, Inc., New YorkGoogle Scholar
  2. 2.
    Carlisle EM (1972) Science 178:619–621PubMedCrossRefGoogle Scholar
  3. 3.
    Schwarz K, Milne DB (1972) Nature 239:333–334PubMedCrossRefGoogle Scholar
  4. 4.
    Carlisle EM (1976) J Nutr 106:478–484PubMedGoogle Scholar
  5. 5.
    Carlisle EM (1986) Silicon. In Mertz W (ed) Trace Elements in Man and Animals, 5th Ed. Academic, New York, Vol. 2, pp 373–390Google Scholar
  6. 6.
    Schwarz K (1973) Proc Natl Acad Sci 70:1608–1612PubMedCrossRefGoogle Scholar
  7. 7.
    Carlisle EM (1979) Fed Proc 38:553Google Scholar
  8. 8.
    Heinegard D, Oldberg A (1989) FASEB J 3:2042–2051PubMedGoogle Scholar
  9. 9.
    Carlisle EM (1970) Science 167:279–280PubMedCrossRefGoogle Scholar
  10. 10.
    Carlisle EM (1981) Calc Tiss Int 33:27–34CrossRefGoogle Scholar
  11. 11.
    Beosel LF, Fernandes MH, Reiss RL (2004) J Biomed Mater Res B Appl Biomater 70(2):368–377CrossRefGoogle Scholar
  12. 12.
    De Aza PN, Luklinska ZB, Anseau M (2005) J Biomed Mater Res B Appl Biomater 73(1):54–60PubMedGoogle Scholar
  13. 13.
    Liu X, Fu RK, Poon RW, Chen P, Chu PK, Ding C (2004) Biomaterials 25(25):5575–5581PubMedCrossRefGoogle Scholar
  14. 14.
    Tamura J, Kitsugi T, Tida H, Fugita H, Nakamura T, Kokubo T, Yoshihara S (1997) Clin Orthop Relat Res 343:183–191PubMedCrossRefGoogle Scholar
  15. 15.
    Carlisle EM (1974) Fed Proc 33:1758–1766PubMedGoogle Scholar
  16. 16.
    Carlisle EM (1986) Ciba Found Symp 121:123–139PubMedCrossRefGoogle Scholar
  17. 17.
    Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) J Bone Miner Res 11(6):707–730PubMedCrossRefGoogle Scholar
  18. 18.
    Tucker KL (2003) Curr Pharm Res 9(32):2687–2704CrossRefGoogle Scholar
  19. 19.
    Emerick RJ, Kayongo-Male H (1990a) J Nutr Biochem 1:35–40PubMedCrossRefGoogle Scholar
  20. 20.
    Kayongo-Male H (1974) Manganese Nutrition of the Pig. PhD. Dissertation. Michigan State University, East LansingGoogle Scholar
  21. 21.
    National Research Council (1994) Nutrient Requirements of Poultry. 9th Edition, National Academy, Washington, DCGoogle Scholar
  22. 22.
    Stewart SR, Emerick RJ, Kayongo-Male H (1993) J Anim Sci 71:946–954PubMedGoogle Scholar
  23. 23.
    Oser BL (1965) Hawk's Physiological chemistry, 14th ed.. McGraw-Hill, New YorkGoogle Scholar
  24. 24.
    Emerick RJ, Kayongo-Male H (1990b) J Nutr Biochem 1:487–492PubMedCrossRefGoogle Scholar
  25. 25.
    SAS (1988) SAS Procedures Guide (Release 6.03 Ed.). SAS Institute Inc, Cary NCGoogle Scholar
  26. 26.
    Steel RGD, Torrie JH (1980) Principles and Procedures of Statistics: A Biomedical Approach, 2nd ed.nd edn. McGraw-Hill, New YorkGoogle Scholar
  27. 27.
    Seaborn CD, Nielsen FH (1994) Biol Trace Elem Res 42(2):151–164PubMedCrossRefGoogle Scholar
  28. 28.
    Burnstein AH, Zika JM, Heiple KG, Klein L (1975) J Bone and Joint Surgery 57A:956–961Google Scholar
  29. 29.
    Bronner F, Stein WD (1996) J Nutr 125(7S):1987–1995Google Scholar

Copyright information

© Humana Press Inc. 2008

Authors and Affiliations

  1. 1.Department of Biology and MicrobiologySouth Dakota State UniversityBrookingsUSA
  2. 2.Department of Agricultural & Biosystems EngineeringSouth Dakota State UniversityBrookingsUSA

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