Biological Trace Element Research

, Volume 120, Issue 1–3, pp 51–60 | Cite as

The Interaction Between Selenium Status, Sex Hormones, and Thyroid Metabolism in Adolescent Girls in the Luteal Phase of their Menstrual Cycle

  • Paweł Zagrodzki
  • Ryszard Ratajczak
  • Renata Wietecha-Posłuszny
Article

Abstract

The objective of the present work was to study all physiological relationships among selenium status (SeS), sex hormones secretion (SH), and thyroid metabolism (ThM) in healthy adolescent girls, at one time. Forty-four girls aged 13.4–16.6 years (mean age, 14.5 ± 0.5 years) entered the statistical model. Parameters reflecting SeS: plasma selenium concentration (Se) and plasma glutathione peroxidase activity (GPX3); SH: serum estradiol (E2) and progesterone (P4); age of menarche (AoM); and ThM: thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), antithyroid peroxidase antibodies (anti-TPO) in serum, and thyroid volume (ThV), were determined, and the interactions between them were evaluated by means of the partial least squares method (PLS). PLS method was, for the first time, successfully applied to the problem of selenium and hormone interactions and revealed that selenium status and female reproductive system are interrelated and affect thyroid physiology in adolescent girls in the luteal phase. The strongest associations were revealed for the pairs of parameters, Se and fT4/fT3, Se and P4, the modest ones for the pairs, Se and ThV, P4 and fT4/fT3, Se and AoM, and P4 and AoM. There was no correlation between E2, GPX3, and TSH, and any other considered parameter. Se and P4 had the greatest influence on ThM parameters.

Keywords

Selenium Thyroid function Human reproductive system Partial least squares method 

Abbreviations

anti-TPO

antithyroid peroxidase antibodies

AoM

age of menarche

E2

serum estradiol

fT3

free triiodothyronine

fT4

free thyroxine

fT4/fT3

free thyroxine/free triiodothyronine ratio

GPX

glutathione peroxidase

GPX3

plasma glutathione peroxidase activity

P4

serum progesterone

PLS

partial least squares method

RBC

red blood cells

SH

sex hormones secretion

Se

plasma selenium concentration

SeS

selenium status

T3

triiodothyronine

T4

thyroxine

T4/T3

thyroxine/triiodothyronine ratio

ThM

thyroid metabolism

TSH

thyroid stimulating hormone

ThV

thyroid volume

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Paweł Zagrodzki
    • 1
    • 4
  • Ryszard Ratajczak
    • 2
  • Renata Wietecha-Posłuszny
    • 3
  1. 1.Department of Food Chemistry and Nutrition, Medical CollegeJagiellonian UniversityKrakówPoland
  2. 2.Specialist Centre of Therapy of Children and AdolescentsOutpatient Clinic for Paediatric EndocrinologyKrakówPoland
  3. 3.Department of Analytical Chemistry, Faculty of Chemistry, Laboratory for Forensic ChemistryJagiellonian UniversityKrakówPoland
  4. 4.Laboratory of Physical Chemistry and RadioisotopesHenryk Niewodniczański Institute of Nuclear PhysicsKrakówPoland

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