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Structure, Molecular Modification, and Anti-radiation Activity of Melanin from Lachnum YM156 on Ultraviolet B-Induced Injury in Mice

  • Shenglan Li
  • Liuqing Yang
  • Jinglei Li
  • Tingting Chen
  • Ming YeEmail author
Article
  • 39 Downloads

Abstract

The purpose of this study was to examine the protective effects of intracellular homogeneous melanin produced by Lachnum YM156 (LIM) against ultraviolet B (UVB) induced damage in mice. The possible structural formula of the LIM was concluded based on elemental analysis, ultraviolet–visible spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The LIM was modified by arginine to improve its water solubility and biological activities. LIM and ALIM show significant anti-radiation activity in which LIM and ALIM protect the skin under UV radiation. Results indicate that activities of anti-oxidant enzymes in skin were improved after treatment of LIM or ALIM. In addition, LIM and ALIM inhibited over expression of the pro-inflammatory cytokines, including interleukin (IL)-1α, IL-1β, and IL-6 and tumor necrosis factor-α (TNF-α). The protection ability of ALIM was higher than that of LIM at the same dose. Thus, applied LIM and ALIM may be a promising radiation-protective agent.

Keywords

Melanin Structural formula Modification Anti-radiation Pro-inflammatory cytokine 

Notes

Funding Information

This work was financially supported by the National Natural Science Foundation of China (31270060).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Shenglan Li
    • 1
  • Liuqing Yang
    • 1
  • Jinglei Li
    • 1
  • Tingting Chen
    • 1
  • Ming Ye
    • 1
    Email author
  1. 1.School of Food and Biological EngineeringHefei University of TechnologyHefeiChina

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