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Half Sandwich Rhodium(III) and Iridium(III) Complexes as Cytotoxic and Metallonuclease Agents

  • Pankajkumar A. Vekariya
  • Parag S. Karia
  • Bhupesh S. Bhatt
  • Mohan N. Patel
Article
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Abstract

Half sandwich complexes of the type [(η5-C5Me5)M(L1–3)Cl]Cl.2H2O were synthesized using [{(η5-C5Me5)M(μ-Cl)Cl}2], where M = Rh(III)/Ir(III) and L1–3 = pyrimidine-based ligands. The complexes were characterized by spectral analysis. DNA interaction studies by absorption titration and hydrodynamic measurement and suggest intercalative mode of binding of complexes with CT-DNA. The molecular docking study also supports intercalation of the complexes between the stacks of nucleotide base pairs. The gel electrophoresis assay demonstrated the ability of the complexes to interact and cleave plasmid DNA. Minimum inhibitory concentrations (MIC) of the complexes were investigated by the microdilution broth method. The cytotoxic properties of the metal complexes were evaluated using brine shrimp lethality bioassay.

Keywords

Half sandwich compounds Rh(III)/Ir(III) metal complexes NMR Molecular docking 

Notes

Acknowledgements

We are thankful to the Head, Department of Chemistry, Sardar Patel University, India for making it convenient to work in a laboratory.

Funding Information

This study was financially supported by the University Grant Commission for providing under the scheme “UGC-CAS” and BSR One Time Grant.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12010_2018_2835_MOESM1_ESM.docx (2.6 mb)
ESM 1 (DOCX 2707 kb)

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Authors and Affiliations

  1. 1.Department of ChemistrySardar Patel UniversityVallabh VidyanagarIndia

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