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Applied Biochemistry and Biotechnology

, Volume 179, Issue 5, pp 819–829 | Cite as

Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress

  • Ying Liu
  • Mingming Zhai
  • Fan Guo
  • Tengrui Shi
  • Jiangzheng Liu
  • Xin Wang
  • Xiaodi Zhang
  • Da JingEmail author
  • Chunxu HaiEmail author
Article

Abstract

Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which is one of the most important chronic noncommunicable diseases. Effective and feasible strategies to treat IR are still urgently needed. Previous research studies reported that whole body vibration (WBV) was beneficial for IR in clinical; however, its underlying mechanisms remains unknown. In the present study, db/db mice were treated with WBV administration 60 min/day for 12 weeks and the impaired insulin sensitivity was improved. Besides, liver steatosis was also ameliorated. Further explorations revealed that WBV could reduce the expression of SREBP1c and increase the expression of GSH-Px and consequently suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to ameliorate liver steatosis and thus improves insulin resistance in db/db mice. Therefore, WBV administration is a promising treatment for individuals who suffered from central obesity and IR.

Keywords

Insulin resistance Liver steatosis Oxidative stress Glutathione peroxidases Whole body vibration 

Notes

Acknowledgments

This work was supported by Program for Chankiang Scholars, Innovative Research Team in University (PCSIRT) and National Nature Scientific Foundation (NSFC-81473010 and NSFC-3140040159). This work was also supported by the Natural Science Foundation of Shaanxi Province (2014JQ4135).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ying Liu
    • 1
  • Mingming Zhai
    • 2
  • Fan Guo
    • 3
  • Tengrui Shi
    • 1
  • Jiangzheng Liu
    • 1
  • Xin Wang
    • 1
  • Xiaodi Zhang
    • 1
  • Da Jing
    • 2
    Email author
  • Chunxu Hai
    • 1
    Email author
  1. 1.Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public HealthThe Fourth Military Medical UniversityXi’anPeople’s Republic of China
  2. 2.Department of Biomedical EngineeringThe Fourth Military Medical UniversityXi’anPeople’s Republic of China
  3. 3.Department of Radiology, Xijing HospitalThe Fourth Military Medical UniversityXi’anPeople’s Republic of China

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