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Novel 1,5,7-Trihydroxy-3-Hydroxy Methyl Anthraquinone Isolated from Terrestrial Streptomyces sp. (eri-26) with Antimicrobial and Molecular Docking Studies

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Abstract

Streptomyces sp. isolate ERI-26 was obtained from the Nilgiris forest soil of Western Ghats, Tamil Nadu, India. Novel anthraquinone compound was isolated from the active fraction 5; it was identified by spectroscopical data using UV, IR, NMR and MASS. The isolated compound 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone was tested against bacteria and fungi at minimum inhibitory concentration level. The compound showed significant antimicrobial activity against bacteria, Staphylococcus aureus at 125 μg/ml, Staphylococcus epidermidis at 62.5 μg/m, Bacillus subtilis at 31.25 μg/ml, fungi; Epidermophyton floccosum at 62.5 μg/ml, Aspergillus niger at 31.25 μg/ml, Aspergiller flavus at 31.25 μg/ml, Trichophyton rubrum at 62.5 μg/ml and Botrytis cinerea at 62.5 μg/ml. The isolated compound was subjected to molecular docking studies for the inhibition of TtgR, topoisomerase IV and AmpC β-lactamase enzymes which are targets for antimicrobials. Docking studies of the compound showed low docking energy indicating its usefulness as antimicrobial agent. 1,5,7-Trihydroxy-3-hydroxy methyl anthraquinone is new, and its antimicrobial and molecular docking properties are reported for the first time.

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Acknowledgments

This project was supported by King Saud University, Deanship Scientific Research, College of Science, Research Center.

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Authors and Affiliations

  1. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh-11451, Saudi Arabia

    V. Duraipandiyan, N. A. AL-Dhabi & M. Valan Arasu

  2. Entomology Research Institute, Loyola College, Chennai, 600034, India

    C. Balachandran, M. Karunai Raj & S. Ignacimuthu

Authors
  1. V. Duraipandiyan
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  2. N. A. AL-Dhabi
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  3. C. Balachandran
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  4. M. Karunai Raj
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  5. M. Valan Arasu
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  6. S. Ignacimuthu
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Correspondence to V. Duraipandiyan.

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Duraipandiyan, V., AL-Dhabi, N.A., Balachandran, C. et al. Novel 1,5,7-Trihydroxy-3-Hydroxy Methyl Anthraquinone Isolated from Terrestrial Streptomyces sp. (eri-26) with Antimicrobial and Molecular Docking Studies. Appl Biochem Biotechnol 174, 1784–1794 (2014). https://doi.org/10.1007/s12010-014-1157-y

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  • DOI: https://doi.org/10.1007/s12010-014-1157-y

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