Applied Biochemistry and Biotechnology

, Volume 172, Issue 3, pp 1254–1264 | Cite as

Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

  • Harris Liu
  • Yoojeong Kim
  • Kerrianne Mello
  • John Lovaasen
  • Apoorva Shah
  • Norman Rice
  • Jacqueline H. Yim
  • Daphne Pappas
  • Alexander M. Klibanov
Article

Abstract

The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.

Keywords

N-alkylated polyethylenimine Immobilization by aerosol-assisted plasma deposition Microbicidal coatings Antibacterial Antiviral 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Harris Liu
    • 1
  • Yoojeong Kim
    • 3
  • Kerrianne Mello
    • 3
  • John Lovaasen
    • 5
  • Apoorva Shah
    • 3
  • Norman Rice
    • 3
  • Jacqueline H. Yim
    • 4
  • Daphne Pappas
    • 4
  • Alexander M. Klibanov
    • 1
    • 2
  1. 1.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of Biological EngineeringMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Triton Systems, Inc.ChelmsfordUSA
  4. 4.US Army Research Laboratory, Multifunctional Materials Branch, Weapons & Materials Research DirectorateAberdeen Proving GroundAberdeenUSA
  5. 5.Triton Systems, Inc.FargoUSA

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