Antiviral and Antibacterial Polyurethanes of Various Modalities
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We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).
KeywordsAntiviral Antibacterial Polyurethane Nanoparticles Nanofibers
This work was financially supported by a University of Colorado start-up funding (to DP), a University of Pittsburgh start-up funding (to YW), the U.S. Army Research Office through the Institute for Soldier Nanotechnology at the Massachusetts Institute of Technology (to AMK), and a Martin Family fellowship (to AML). We thank Mr. Amin Famili at the University of Colorado Denver for the DLS measurements.
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