Applied Biochemistry and Biotechnology

, Volume 168, Issue 7, pp 2043–2056 | Cite as

Study of the Release Mechanism of Terminalia chebula Extract from Nanoporous Silica Gel

  • Suparna Chakraborty
  • Manoj Kumar Mitra
  • Mahua Ghosh Chaudhuri
  • Biswanath Sa
  • Satadal Das
  • Rajib Dey
Article
First Online:
Received:
Accepted:

Abstract

Sol/gel-derived silica gel was prepared at room temperature from tetraethyl orthosilicate precursor. The extracts of Terminalia chebula (Haritoki) were entrapped into the porous silica gel. Fourier transform infrared analysis revealed the proper adsorption of herbal values in the nanopores of the silica gel. Porosity was estimated by transmission electron microscope studies. The release kinetics of the extract in both 0.1 N HCl, pH 1.2, and Phosphate-buffer saline (PBS), pH 7.2, were determined using UV–Vis spectroscopy. Different dissolution models were applied to release data in order to evaluate the release mechanisms and kinetics. Biphasic release patterns were found in every formulation for both the buffer systems. The kinetics followed a zero-order equation for first 4 h and a Higuchi expression in a subsequent timeline in the case of 0.1 N HCl. In the case of PBS, the formulations showed best linearity with a first-order equation followed by Higuchi’s model. The sustained release of the extract predominantly followed diffusion and super case II transport mechanism. The release value was always above the minimum inhibitory concentration.

Keywords

Nano porous silica gel Terminalia chebula Kinetics Sustained release MIC 
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Notes

Acknowledgment

One of the authors (S.C) is thankful to the University Grant Commission for the financial assistance and would like to give heartfelt thanks to Mr. Supratim Biswas, Senior Research Scholar of the Department of Metallurgical and Material Engineering, Jadavpur University, for his constant cooperation and support throughout this experimental work.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Suparna Chakraborty
    • 1
  • Manoj Kumar Mitra
    • 2
  • Mahua Ghosh Chaudhuri
    • 1
  • Biswanath Sa
    • 3
  • Satadal Das
    • 4
  • Rajib Dey
    • 2
  1. 1.School of Materials Science and NanotechnologyJadavpur UniversityKolkataIndia
  2. 2.Department of Metallurgical and Material EngineeringJadavpur UniversityKolkataIndia
  3. 3.Department of Pharmaceutical TechnologyJadavpur UniversityKolkataIndia
  4. 4.Department of MicrobiologyPeerless Hospital& B. K. Ray Research CentreKolkataIndia

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