A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases
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Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.
KeywordsIndels Cancer Length distribution
The authors are indebt to Dr. Gabriel Gutiérrez at Departamento de Genética, Universidad de Sevilla, Sevilla, Spain for proofreading this manuscript. This paper is partially supported by Department of Personnel Jiangsu province “Liu Da Ren Cai Gao Feng” grant (07-B-033), and The National Natural Science Foundation of China (No. 30970877).
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