A Law of Mutation: Power Decay of Small Insertions and Small Deletions Associated with Human Diseases
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Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.
KeywordsIndels Cancer Length distribution
The authors are indebt to Dr. Gabriel Gutiérrez at Departamento de Genética, Universidad de Sevilla, Sevilla, Spain for proofreading this manuscript. This paper is partially supported by Department of Personnel Jiangsu province “Liu Da Ren Cai Gao Feng” grant (07-B-033), and The National Natural Science Foundation of China (No. 30970877).
- 3.Temin, H. M. (1988). Evolution of cancer genes as a mutation-driven process. Cancer Research, 48, 1697–1701.Google Scholar
- 5.Pfeifer, G. P., & Besaratinia, A. (2009). Mutational spectra of human cancer. Human Genetics, 24. (Epub ahead of print)Google Scholar
- 9.Ball, E. V., Stenson, P. D., Abeysinghe, S. S., Krawczak, M., Cooper, D. N., & Chuzhanova, N. A. (2005). Microdeletions and microinsertions causing human genetic disease: common mechanisms of mutagenesis and the role of local DNA sequence complexity. Human Mutation, 26, 205–213.CrossRefGoogle Scholar
- 25.Halpern, A. L., & Bruno, W. J. (1998). Evolutionary distances for protein-coding sequences: modeling site-specific residue frequencies. Molecular Biology and Evolution, 15, 910–917.Google Scholar
- 28.Li, K. (2006). Small insertions and deletions is revealed in association with the number of inserted or deleted nucleotides. J Nanhua University, 34(1–2), 9.Google Scholar
- 29.Li, K., Xiao, L., Yin, Y. F., & Zhang, J. (Oct 9-13, 2006) How to associate the somatic mutations and a specific cancer. 56th ASHG, New Orleans, USA.Google Scholar