Annals of Ophthalmology

, Volume 32, Issue 4, pp 307–312 | Cite as

Distribution of catecholaminergic nerve fibers in normal and alkali-injured rabbit corneas

  • Nicola Pescosolido
  • Carlo Cavallotti
  • Marco Artico
  • Daniela Cavallotti
  • Elena Pacella
  • Francesco Gherardi
Original Article


The alkali-burned corneas of 12 rabbits were studied with fluorescence microscopy 1 week, 3 weeks, and 6 months after injury to identify the arrangement of catecholaminergic nerve fibers (CNF) and related levels of norepinephrine. In the wounded corneas, CNF were reduced at both 1 and 3 weeks and were restored by 6 months, as shown by histofluorescent staining. Biochemical results showed that norepinephrine also passes through surviving, degenerating, and regenerating phases.


Rabbit Cornea Corneal Nerve Formaldehyde Vapor Fresh Tissue Weight Substantia Propria 
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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  • Nicola Pescosolido
    • 1
  • Carlo Cavallotti
    • 2
  • Marco Artico
    • 4
  • Daniela Cavallotti
    • 3
  • Elena Pacella
    • 1
  • Francesco Gherardi
    • 1
  1. 1.Department of Ophthalmology, Dr. C. Cavallotti is fromUniversity of Rome “La Sapienza”RomeItaly
  2. 2.Section of Anatomy, Dr. D. Cavallotti is fromUniversity of Rome “La Sapienza”RomeItaly
  3. 3.Second Neurological Clinic, Dr. Artico is fromUniversity of Rome “La Sapienza”RomeItaly
  4. 4.Department of Pharmacology of Natural Molecules and General PhysiologyUniversity of Rome “La Sapienza”RomeItaly

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