Clinical Orthopaedics and Related Research®

, Volume 471, Issue 2, pp 686–687

Letter to the Editor: Is There Really No Benefit of Vertebroplasty for Osteoporotic Vertebral Fractures? A Meta-analysis

  • David S. Jevsevar
  • Stephen I. Esses
  • Deborah S. Cummins
Letter to the Editor


  1. 1.
    Alvarez L, Alcaraz M, Perez-Higueras A, Granizo JJ, de Miguel I, Rossi RE, Quinones D. Percutaneous vertebroplasty: functional improvement in patients with osteoporotic compression fractures. Spine (Phila Pa 1976). 2006;31:1113–1118.Google Scholar
  2. 2.
    American Academy of Orthopaedic Surgeons: Clinical Practice Guideline on the Treatment of Symptomatic Osteoporotic Spinal Compression Fractures. Rosemont, IL, American Academy of Orthopaedic Surgeons, September 2010. Available at: Accessed September 7, 2012.
  3. 3.
    Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, Graves S, Staples MP, Murphy B. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009;361:557–568.PubMedCrossRefGoogle Scholar
  4. 4.
    Diamond TH, Champion B, Clark WA. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med. 2003;114:257–265.PubMedCrossRefGoogle Scholar
  5. 5.
    Farrokhi MR, Alibai E, Maghami Z. Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. J Neurosurg Spine. 2011;14:561–569.PubMedGoogle Scholar
  6. 6.
    Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, Edwards R, Gray LA, Stout L, Owen S, Hollingworth W, Ghdoke B, Annesley-Williams DJ, Ralston SH, Jarvik JG. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009;361:569–579.PubMedCrossRefGoogle Scholar
  7. 7.
    Klazen CA, Lohle PN, de Vries J, Jansen FH, Tielbeek AV, Blonk MC, Venmans A, van Rooij WJ, Schoemaker MC, Juttmann JR, Lo TH, Verhaar HJ, van der Graaf Y, van Everdingen KJ, Muller AF, Elgersma OE, Halkema DR, Fransen H, Janssens X, Buskens E, Mali WP. Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet. 2010;376:1085–1092.PubMedCrossRefGoogle Scholar
  8. 8.
    Rousing R, Andersen MO, Jespersen SM, Thomsen K, Lauritsen J. Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine (Phila Pa 1976). 2009;34:1349–1354.Google Scholar
  9. 9.
    Shi MM, Cai XZ, Lin T, Wang W, Yan SG. Is there really no benefit of vertbroplasty for osteoporotic vertebral fractures? A meta-analysis. Clin Orthop Relat Res. 2012 June 23. [Epub ahead of print]Google Scholar
  10. 10.
    Voormolen MH, van Rooij WJ, Sluzewski M, van der Graaf Y, Lampmann LE, Lohle PN, Juttmann JR. Pain response in the first trimester after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures with or without bone marrow edema. AJNR Am J Neuroradiol. 2006;27:1579–1585.PubMedGoogle Scholar
  11. 11.
    Wang HK, Lu K, Liang CL, Weng HC, Wang KW, Tsai YD, Hsieh CH, Liliang PC. Comparing clinical outcomes following percutaneous vertebroplasty with conservative therapy for acute osteoporotic vertebral compression fractures. Pain Med. 2010;11:1659–1665.PubMedCrossRefGoogle Scholar

Copyright information

© The Association of Bone and Joint Surgeons® 2012

Authors and Affiliations

  • David S. Jevsevar
    • 1
  • Stephen I. Esses
    • 1
  • Deborah S. Cummins
    • 1
  1. 1.American Academy of Orthopaedic SurgeonsRosemontUSA

Personalised recommendations