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Clinical Orthopaedics and Related Research®

, Volume 469, Issue 10, pp 2706–2715 | Cite as

The Role of Growth Factors in Cartilage Repair

  • Lisa A. FortierEmail author
  • Joseph U. Barker
  • Eric J. Strauss
  • Taralyn M. McCarrel
  • Brian J. Cole
Symposium: Clinically Relevant Strategies for Treating Cartilage and Meniscal Pathology

Abstract

Background

Full-thickness chondral defects and early osteoarthritis continue to present major challenges for the patient and the orthopaedic surgeon as a result of the limited healing potential of articular cartilage. The use of bioactive growth factors is under consideration as a potential therapy to enhance healing of chondral injuries and modify the arthritic disease process.

Questions/purposes

We reviewed the role of growth factors in articular cartilage repair and identified specific growth factors and combinations of growth factors that have the capacity to improve cartilage regeneration. Additionally, we discuss the potential use of platelet-rich plasma, autologous-conditioned serum, and bone marrow concentrate preparations as methods of combined growth factor delivery.

Methods

A PubMed search was performed using key words cartilage or chondrocyte alone and in combination with growth factor. The search was open for original manuscripts and review papers and open for all dates. From these searches we selected manuscripts investigating the effects of growth factors on extracellular matrix synthesis and excluded those investigating molecular mechanisms of action.

Results

By modulating the local microenvironment, the anabolic and anticatabolic effects of a variety of growth factors have demonstrated potential in both in vitro and animal studies of cartilage injury and repair. Members of the transforming growth factor-β superfamily, fibroblast growth factor family, insulin-like growth factor-I, and platelet-derived growth factor have all been investigated as possible treatment augments in the management of chondral injuries and early arthritis.

Conclusions

The application of growth factors in the treatment of local cartilage defects as well as osteoarthritis appears promising; however, further research is needed at both the basic science and clinical levels before routine application.

Keywords

Articular Cartilage Cartilage Defect Cartilage Repair International Knee Documentation Committee Bone Marrow Concentrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank Ms Paula Sharp for her technical assistance in generating the manuscript.

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Copyright information

© The Association of Bone and Joint Surgeons® 2011

Authors and Affiliations

  • Lisa A. Fortier
    • 1
    Email author
  • Joseph U. Barker
    • 2
  • Eric J. Strauss
    • 2
  • Taralyn M. McCarrel
    • 1
  • Brian J. Cole
    • 2
  1. 1.Department of Clinical Sciences, VMC C3-181Cornell UniversityIthacaUSA
  2. 2.Midwest Orthopedics at RushChicagoUSA

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