Clinical Orthopaedics and Related Research®

, Volume 468, Issue 11, pp 3047–3055 | Cite as

Injection of Demineralized Bone Matrix With Bone Marrow Concentrate Improves Healing in Unicameral Bone Cyst

  • Claudia Di Bella
  • Barbara Dozza
  • Tommaso Frisoni
  • Luca Cevolani
  • Davide Donati
Symposium: Highlights of the ISOLS/MSTS 2009 Meeting



Unicameral bone cysts are benign lesions that usually spontaneously regress with skeletal maturity; however, the high risk of pathologic fractures often justifies treatment that could reinforce a weakened bone cortex. Various treatments have been proposed but there is no consensus regarding the best procedure.


We compared the healing rates and failures of two methods of cure based on multiple injections of corticosteroid or a single injection of demineralized bone matrix (DBM) in association with bone marrow concentrate (BMC).


We retrospectively reviewed 184 patients who had one of the two treatments for unicameral bone cysts with cortical erosion. Clinical records were reviewed for treatment failures and radiographs for healing in all patients. The minimum followup was 12 months for the Steroids Group (mean, 48 months; range, 12–120 months) and 12 months for the DBM + BMC Group (mean, 20 months; range, 12–28 months).


After one treatment we observed a lower healing rate of cysts treated with multiple injections of steroids compared with the healing after the first injection of DBM + BMC (21% versus 58%, respectively). At last followup, 38% healed with steroids and 71% with DBM + BMC. The rate of failure after one steroid injection was higher than after a single injection of BDM + BMC (63% versus 24%, respectively). We observed no difference in fracture rates after treatment between the two groups.


A single injection of DBM added with autologous bone marrow concentrate appears to provide a higher healing rate with a lower number of failures compared with a single injection of steroids.

Level of Evidence

Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.



We thank Elettra Pignotti for contributions regarding statistical analysis and Enrico Lucarelli for manuscript review.


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Copyright information

© The Association of Bone and Joint Surgeons® 2010

Authors and Affiliations

  • Claudia Di Bella
    • 1
    • 2
  • Barbara Dozza
    • 2
  • Tommaso Frisoni
    • 1
    • 2
  • Luca Cevolani
    • 1
    • 2
  • Davide Donati
    • 1
    • 2
  1. 1.Department of Oncology OrthopaedicRizzoli Orthopaedic InstituteBolognaItaly
  2. 2.Bone Regeneration Laboratory, Codivilla-Putty Research InstituteRizzoli Orthopaedic InstituteBolognaItaly

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