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Clinical Orthopaedics and Related Research®

, Volume 468, Issue 11, pp 2969–2975 | Cite as

Chondrosarcoma of Bone: Lessons From 46 Operated Cases in a Single Institution

  • Olavo Pires de CamargoEmail author
  • André Mathias Baptista
  • Marcelo Junqueira Atanásio
  • Daniel Reis Waisberg
Symposium: Highlights of the ISOLS/MSTS 2009 Meeting

Abstract

Background

Bone chondrosarcomas are rare malignant tumors that have variable biologic behavior, and their treatment is controversial. For low-grade tumors, there is no consensus on whether intralesional en bloc resections are the best treatment.

Questions/purposes

We therefore compared patients with Grade 1 and Grade 2 primary central chondrosarcomas to (1) determine difference in survival and (2) local recurrence rates; and (3) determine any association of histological grade with some clinical and demographic characteristics.

Methods

We retrospectively reviewed 46 patients with grade 1 and 2 chondrosarcomas. There were 25 men and 21 women with a mean age of 43 years (range, 17–79 years). Minimum followup was 32 months (mean, 99 months; range, 32–312 months) for the patients who remained alive in the end of the study. Twenty-three of the tumors were intracompartmental (Enneking A); of these, 19 were Grade 1 and 4 were Grade 2. Twenty-three tumors were extracompartmental (Enneking B); of these, 4 were Grade 1 and 19 were Grade 2. Twenty-five patients underwent intralesional resection, 18 had wide resection, and three had amputations.

Results

The overall survival rate was 94% and the disease-free survival rate was 90%. Among the 23 Grade 1 tumors, we observed six local recurrences and none of these patients died; among the 23 Grade 2 tumors, 10 recurred and two patients died. Local recurrence negatively influenced survival.

Conclusions

For lesions with radiographic characteristics of intracompartmental Grade 1 chondrosarcoma, we believe intralesional resection followed by electrocauterization and cement is the best treatment. When the imaging suggests aggressive (Grade 2 or 3) chondrosarcoma, then wide resection is promptly indicated.

Level of Evidence

Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.

Keywords

Local Recurrence Histological Grade Chondrosarcomas Local Recurrence Rate Soft Tissue Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank Tomaz Puga Leivas for his contribution in the statistical analysis of this study.

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Copyright information

© The Association of Bone and Joint Surgeons® 2010

Authors and Affiliations

  • Olavo Pires de Camargo
    • 1
    Email author
  • André Mathias Baptista
    • 2
  • Marcelo Junqueira Atanásio
    • 3
  • Daniel Reis Waisberg
    • 3
  1. 1.Department of OrthopaedicsUniversity of São PauloSão PauloBrazil
  2. 2.Orthopaedic Oncology GroupUniversity of São PauloSão PauloBrazil
  3. 3.University of São Paulo Medical SchoolSão PauloBrazil

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