Perioperative Dexamethasone Does Not Affect Functional Outcome in Total Hip Arthroplasty

  • Stephane G. Bergeron
  • Kenneth J. Kardash
  • Olga L. Huk
  • David J. Zukor
  • John Antoniou
Symposium: Advanced Techniques for Rehabilitation after Total Hip and Knee Arthroplasty


Current trends in orthopaedic surgery have explored different forms of adjuvant treatments to minimize postoperative pain and the risk of nausea and vomiting. A small single preoperative dose of dexamethasone, as part of a comprehensive multimodal analgesic regimen in low-risk patients undergoing total hip arthroplasty (THA), provides antiemetic and opioid-sparing effects but the longer-term effects on pain, complications, or function are not known. We therefore asked whether such a routine would affect longer-term pain, complications, or function. Fifty patients undergoing elective primary THA using spinal anesthesia were initially randomized to receive either dexamethasone (40 mg intravenous) or saline placebo. The patients, anesthesiologists, nurses, and research coordinators were blinded to the study arms. The functional outcome was measured using the Harris hip score. Outcomes were assessed 6 weeks and 1 year postoperatively. We observed no difference in resting pain between the two groups at either time period. Both groups had similar functional outcome scores for the total Harris hip score and individual scoring items at each followup interval. There were no wound complications, deep infections, or osteonecrosis in the contralateral hip at 1-year followup. We recommend the addition of a small single preoperative dose of dexamethasone to a comprehensive multimodal analgesic regimen in low-risk patients given its immediate antiemetic and opioid-sparing effects, and absence of subsequent effects.

Level of Evidence: Level II, therapeutic study (prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence.


Dexamethasone Osteonecrosis Ketorolac Postoperative Nausea Dexamethasone Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Alain Petit for his help in preparing the manuscript, and Maricar Alminia and Laura Des Rosiers for their help in administration of the questionnaires and recording the clinical data.


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Copyright information

© The Association of Bone and Joint Surgeons 2009

Authors and Affiliations

  • Stephane G. Bergeron
    • 1
  • Kenneth J. Kardash
    • 2
  • Olga L. Huk
    • 3
  • David J. Zukor
    • 3
  • John Antoniou
    • 3
  1. 1.Division of Orthopaedic Surgery, Montreal General HospitalMcGill University Health CentreMontrealCanada
  2. 2.Department of AnesthesiaSMBD-Jewish General HospitalMontrealCanada
  3. 3.Department of OrthopaedicsSMBD-Jewish General HospitalMontrealCanada

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