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Science and Engineering Ethics

, Volume 25, Issue 1, pp 113–128 | Cite as

Obstacles to Widening Biosample Research

  • Flora ColledgeEmail author
  • Jakob Passweg
  • Bernice ElgerEmail author
Original Paper
  • 83 Downloads

Abstract

Switzerland has an excellent culture of medical research and is a melting pot for medical experts with international expertise. Nevertheless, as in other countries, the resources available to medical researchers are not being fully used. Biological samples, which enable a host of medical research studies to be carried out without invasive methods involving patients, are frequently left unused or forgotten. The aim of this study is to examine the experiences of biobank stakeholders regarding the use or underuse of biosamples, in order to develop paths to optimize biosample research. Interviews were carried out with 36 biobank stakeholders in Switzerland concerning their experiences with biosample use, and the possible obstacles at each stage of the process. Interviews revealed that standard operating procedures were the most frequently cited obstacle, although these were not judged to be severe hindrances. Despite a stated desire to develop biosample research, skepticism of sharing networks and wariness of new partnerships were strong themes. Biobanking still functions as an emerging field, in which exchange practices have yet to be established at the national and international levels. Sample exchange continues to function largely based on personal contacts; while this is an inherent feature of competitive medical research, opportunities for large-scale studies may be lost due to excessive caution.

Keywords

Biobank Biosample Collaboration Sharing 

Notes

Acknowledgements

The authors would like to acknowledge the contribution of Heidi Howard, who developed the interview guide, supervised the data collection, and assisted with the coding; David Shaw, who assisted in developing codes and data analysis; and Kirsten Persson, who also give input into coding and evolution of the project. Flora Colledge’s doctoral research was funded in part by the Käthe-Zingg-Schwichtenberg Fonds of the Swiss Academy of Medical Science.

Compliance with Ethical Standards

Conflict of interest

None.

References

  1. Asslaber, M., & Zatloukal, K. (2007). Biobanks: Transnational, European and global networks. Briefings in Functional Genomics & Proteomics, 6(3), 193–201. doi: 10.1093/bfgp/elm023.CrossRefGoogle Scholar
  2. Betsou, F., Rimm, D. L., Watson, P. H., Womack, C., Hubel, A., Coleman, R. A., Horn, L., Terry, S. F., Zeps, N., Clark, B. J., Miranda, L. B., Hewitt, R. & Elliott, G. D. (2010). What are the biggest challenges and opportunities for biorepositories in the next three to five years? Biopreservation and Biobanking. doi: 10.1089/bio.2010.8210.Google Scholar
  3. Colledge, F., & Elger, B. (2015). Getting a fair share: Attitudes and perceptions of biobank stakeholders concerning the fairness of sample sharing. Bioethics, 29(6), 424–430. doi: 10.1111/bioe.12134.CrossRefGoogle Scholar
  4. Colledge, F., Elger, B., & Howard, H. C. (2013a). A review of the barriers to sharing in biobanking biopreservation and biobanking, 11(6), 339–346. doi: 10.1089/bio.2013.0039.CrossRefGoogle Scholar
  5. Colledge, F. M., Elger, B. S., & Shaw, D. M. (2013b). “Conferring authorship”: Biobank stakeholders’ experiences with publication credit in collaborative research. PLoS ONE, 8(9), e76686. doi: 10.1371/journal.pone.0076686.CrossRefGoogle Scholar
  6. Colledge, F., Persson, K., Elger, B., & Shaw, D. (2014). Sample and data sharing barriers in biobanking: Consent, committees, and compromises. Annals of Diagnostic Pathology, 18(2), 78–81. doi: 10.1016/j.anndiagpath.2013.12.002.CrossRefGoogle Scholar
  7. Dillner, J., & Andersson, K. (2011). Biobanks collected for routine healthcare purposes: Build-up and use for epidemiologic research. Methods in Molecular Biology, 675, 113–125. doi: 10.1007/978-1-59745-423-0_4.CrossRefGoogle Scholar
  8. Gibbons, S. M. C. (2009). Regulating biobanks: A twelve-point typological tool. Medical Law Review, 17(3), 313–346. doi: 10.1093/medlaw/fwp016.CrossRefGoogle Scholar
  9. Hagen, H. E., & Carlstedt-Duke, J. (2004). Building global networks for human diseases: Genes and populations. Nature Medicine, 10(7), 665–667. doi: 10.1038/nm0704-665.CrossRefGoogle Scholar
  10. Harris, J. R., Burton, P., Knoppers, B. M., Lindpaintner, K., Bledsoe, M., Brookes, A. J., Budin-Ljosne, I., Chisholm, R., Cox, D., Deschênes, M., Fortier, I., Hainaut, P., Hewitt, R., Kaye, J., Litton, J. E., Metspalu, A., Ollier, B., Palmer, L. J., Palotie, A., Pasterk, M., Perola, M., Riegman, P. H. J., van Ommen, G. J., Yuille, M. & Zatloukal, K. (2012). Toward a roadmap in global biobanking for health. European Journal of Human Genetics, 20(11), 1105–1111. doi: 10.1038/ejhg.2012.96.
  11. Kiehntopf, M., & Krawczak, M. (2011). Biobanking and international interoperability: Samples. Human Genetics. doi: 10.1007/s00439-011-1068-8.Google Scholar
  12. Mehrjahresprogramm 20122016. Planungseingabe zuhanden der Bundesbehörden. (2010). Bern: Stämpfli Publikationen AG.Google Scholar
  13. Meier-Abt, P. (2013). Die schweiz braucht mehr biobank. Digma, 13(3), 81–83.Google Scholar
  14. Rogers, J., Carolin, T., Vaught, J., & Compton, C. (2011). Biobankonomics: A taxonomy for evaluating the economic benefits of standardized centralized human biobanking for translational research. JNCI Monographs, 2011(42), 32–38. doi: 10.1093/jncimonographs/lgr010.CrossRefGoogle Scholar
  15. Rothmayr, C. (2009). Biobanks: Governance in comparative perspective—edited by Herbert Gottweis and Alan Petersen. Governance, 22(4), 759–761. doi: 10.1111/j.1468-0491.2009.01461_6.x.CrossRefGoogle Scholar
  16. Shaw, D. M., Elger, B. S., & Colledge, F. (2014). What is a biobank? Differing definitions among biobank stakeholders. Clinical Genetics, 85(3), 223–227. doi: 10.1111/cge.12268.CrossRefGoogle Scholar
  17. Vaught, J., Kelly, A., & Hewitt, R. (2009). A review of international biobanks and networks: Success factors and key benchmarks. Biopreservation and Biobanking, 7(3), 143–150. doi: 10.1089/bio.2010.0003.CrossRefGoogle Scholar
  18. Vaught, J., Rogers, J., Carolin, T., & Compton, C. (2011). Biobankonomics: Developing a sustainable business model approach for the formation of a human tissue biobank. JNCI Monographs, 2011(42), 24–31. doi: 10.1093/jncimonographs/lgr009.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.Department of Sport, Exercise and HealthUniversity of BaselBaselSwitzerland
  2. 2.Hematology ClinicUniversity Hospital of BaselBaselSwitzerland
  3. 3.Institute for Biomedical EthicsUniversity of BaselBaselSwitzerland

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