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What is the Relevance of Gastric Microbiota Beyond H. pylori?

  • Kerstin Schütte
  • Peter Malfertheiner
  • Christian SchulzEmail author
Stomach (P Malfertheiner, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Stomach

Abstract

Purpose

The role of Helicobacter pylori as key factor in gastric inflammation and the development of (pre-)cancerous lesions is undisputable. As an open system, the human upper gastrointestinal tract harbors a complex bacterial community which is highly impacted by the absence or presence of H. pylori. The interaction between other bacteria and H. pylori might impact on gastric carcinogenesis.

Recent findings

Several studies demonstrated differences in the composition of the gastric bacterial community in different stages of gastritis and between samples from tumor and adjacent tissue. In addition, animal studies demonstrated an increased and accelerated development of precancerous lesions in mice colonized with intestinal flora and H. pylori compared with mice mono-infected with H. pylori.

Conclusion

Other bacteria beyond H. pylori enter the focus in research on gastric carcinogenesis. However, we are still far from a thorough understanding of the pathophysiology of host-microbiota interaction and its impact on the development of malignant and precancerous changes.

Keywords

Helicobacter pylori Stomach H. pylori Gastric microbiome Microbiota Precancerous lesions 

Notes

Compliance with Ethical Standards

Conflict of Interest

Kerstin Schütte, Peter Malfertheiner, and Christian Schulz declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Kerstin Schütte
    • 1
    • 3
  • Peter Malfertheiner
    • 2
  • Christian Schulz
    • 2
    • 3
    Email author
  1. 1.Department of Internal Medicine and GastroenterologyNiels-Stensen-Kliniken, MarienhospitalOsnabrückGermany
  2. 2.Department of Internal Medicine IIHospital of the Ludwig Maximilian University of MunichMunichGermany
  3. 3.Department of Gastroenterology, Hepatology and Infectious DiseasesOtto-von-Guericke-UniversityMagdeburgGermany

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