Current Treatment Options in Gastroenterology

, Volume 16, Issue 4, pp 605–615 | Cite as

Helicobacter pylori Infection: New Facts in Clinical Management

  • Peter MalfertheinerEmail author
  • Marino Venerito
  • Christian Schulz
Stomach (P Malfertheiner, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Stomach



The global prevalence of Helicobacter pylori remains high in spite of its significant downwards trajectory in many regions. The clinical management of H. pylori infection merits guidance to meet ongoing challenges on whom and how to test, prevent, and cure related diseases.

Recent findings

Several international guidelines and consensus reports have updated the management strategies for cure of the H. pylori infection. The definition of H. pylori gastritis as an infectious disease independent of whether or not presenting with clinical manifestations and symptoms has broadened the use of the test and treat strategy. Patients on selected long-term medications, such as aspirin, other anti-platelet agents, NSAIDs, and PPIs should be considered for H. pylori test and treat. Important progress is made with initiatives in primary and secondary gastric cancer prevention. Uncertainties persist in the interpretation of the role of H. pylori in association with extragastric diseases. Selection of therapies needs to address individual antibiotic resistance and regional surveillance of resistance for the adoption of an effective treatment algorithm.


Clinical aspects of H. pylori infection have evolved over time and the therapeutic management requires continuous adaptation. A vaccine is still a non-fulfilled promise. The future will tell us more about the role of H. pylori in interactions with the gut microbiome.


Helicobacter pylori Stomach H. pylori Microbiome Gastritis Test & treat Antibiotic resistance 


Compliance with Ethical Standards

Conflict of Interest

Peter Malfertheiner is involved in speakers bureau/or consulting: Biocodex, Biohit, Danone, Mayoly- Spindler. Marino Venerito declares that he has no conflict of interest. Christian Schulz declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Peter Malfertheiner
    • 1
    • 2
    Email author
  • Marino Venerito
    • 1
  • Christian Schulz
    • 2
  1. 1.Department of Gastroenterology, Hepatology and Infectious DiseasesOtto-von-Guericke University HospitalMagdeburgGermany
  2. 2.Department of Medicine IIUniversity Hospital, LMUMunichGermany

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