Treat to Target in Inflammatory Bowel Disease
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With the expanding armamentarium in IBD the current treatment targets can be reached. By optimally using our drugs we can avoid long-term complications in IBD. For this the therapeutic strategy has to be changed from a clinically driven approach to a target-driven strategy. Currently mucosal healing, normalization of biomarkers, histological healing, and healing on abdominal imaging are proposed targets. Correct phenotyping of the patient before initiation of therapy is mandatory. Once treatment is initiated a continuous re-evaluation with consequent adaptation of the treatment when goals are not (yet) reached is needed. Both escalation and de-escalation should be considered. Drug levels can be used as a guidance to reach these targets.
KeywordsTreat to target Mucosal healing Biomarkers MRE Histological healing IBD
Compliance with Ethical Standards
Conflict of Interest
Peter Bossuyt reports grants from Abbvie, consultancy or speakers fees from Mundipharma, MSD, Robarts, and Hospira, outside the submitted work.
Séverine Vermeire reports grants from Abbvie, Takeda, MSD, and consultancy or speakers fees paid to the institution from Abbvie, Takeda, MSD, Pfizer, Genentech/Roche, Galapagos, Hospira, Mundipharma, J&J, Shire, Ferring, and Cellgene.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
References and Recommended Reading
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