Treat to Target in Inflammatory Bowel Disease

  • Peter Bossuyt
  • Séverine VermeireEmail author
Inflammatory Bowel Disease (G Lichtenstein, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Inflammatory Bowel Disease

Opinion statement

With the expanding armamentarium in IBD the current treatment targets can be reached. By optimally using our drugs we can avoid long-term complications in IBD. For this the therapeutic strategy has to be changed from a clinically driven approach to a target-driven strategy. Currently mucosal healing, normalization of biomarkers, histological healing, and healing on abdominal imaging are proposed targets. Correct phenotyping of the patient before initiation of therapy is mandatory. Once treatment is initiated a continuous re-evaluation with consequent adaptation of the treatment when goals are not (yet) reached is needed. Both escalation and de-escalation should be considered. Drug levels can be used as a guidance to reach these targets.


Treat to target Mucosal healing Biomarkers MRE Histological healing IBD 


Compliance with Ethical Standards

Conflict of Interest

Peter Bossuyt reports grants from Abbvie, consultancy or speakers fees from Mundipharma, MSD, Robarts, and Hospira, outside the submitted work.

Séverine Vermeire reports grants from Abbvie, Takeda, MSD, and consultancy or speakers fees paid to the institution from Abbvie, Takeda, MSD, Pfizer, Genentech/Roche, Galapagos, Hospira, Mundipharma, J&J, Shire, Ferring, and Cellgene.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

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© Springer Science+Business Media, LLC 2016

Authors and Affiliations

  1. 1.Department of Gastroenterology, University Hospitals LeuvenKULeuven–University of LeuvenLeuvenBelgium
  2. 2.Department of Gastroenterology, Imelda GI Clinical Research CentreImelda ziekenhuisBonheidenBelgium

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