Current Treatment Options in Gastroenterology

, Volume 12, Issue 3, pp 350–358 | Cite as

Total Pancreatectomy With Islet Cell Auto-Transplantation: Update and Outcomes From Major Centers

  • Noaman S. Ali
  • R. Matthew Walsh
Pancreas (T Stevens, Section Editor)

Opinion statement

Chronic pancreatitis is the result of irreversible damage to pancreatic acinar cells, and can result in debilitating chronic pain for patients. Treatment centers on pain relief, often with chronic narcotic use. Surgical therapy consists of both resection procedures to remove affected pancreatic parenchyma and drainage procedures to facilitate drainage of the main pancreatic duct. Total pancreatectomy historically was utilized in extreme cases due to the brittle glucose control that followed from the total loss of islet cells. Total pancreatectomy with islet cell auto-transplantation (TP-AIT) is gaining in popularity due to the maintenance of beta cell mass and the ability of patients to potentially be insulin independent post-operatively. TP-AIT is very helpful in the treatment of pain for patients with chronic pancreatitis. The overall majority of patients have an improvement in pain and quality-of-life scores. AIT also allows the majority of patients to have minimal insulin requirements post-operatively. With proper patient selection, these outcomes can be achieved.


Chronic pancreatitis Islet cell auto-transplantation Outcomes Total pancreatectomy 


Compliance with Ethics Guidelines

Conflict of Interest

Noaman S. Ali declares that he has no conflict of interest.

R. Matthew Walsh declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.Cleveland Clinic, Digestive Disease InstituteClevelandUSA

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