Cardiotoxicities of Modern Treatments in Breast Cancer

  • Susan DentEmail author
  • Chiara Melloni
  • Josee Ivars
  • Sarah Sammons
  • Gretchen Kimmick
Cardio-oncology (M Fradley, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardio-oncology


Purpose of review

This paper will focus on novel breast cancer therapies used in clinical practice today, as well as review our understanding of standard therapies and their potential impact on cardiovascular health.

Recent findings

Established and novel treatments such as anthracyclines, HER2-targeted agents, and immunotherapy have contributed to improvements in breast cancer outcomes; however, these treatments may be associated with an increased risk of cardiovascular injury. The number of available breast cancer treatments continues to expand, as does the need for health care providers to understand the potential impact of these treatments on cardiovascular health.


Collaborative approaches in the development of risk stratification, prevention, and surveillance strategies for patients exposed to established and novel breast cancer treatments will facilitate improvements in patient outcomes without compromising their cardiovascular health.


Breast cancer Novel treatments Cardiac injury 



The authors would like to thank Erin Campbell, MS, for her editorial contributions to this manuscript.

Compliance with Ethical Standards

Conflict of Interest

Susan Dent has received honorarium from Novartis, Pfizer and Hoffman La-Roche. Chiara Melloni receives support for research from the NICHD (HHSN27500027, HHSN27500043). All industry disclosures are available at: Josee Ivars declares no potential conflicts of interest. Sarah Sammons reports a grant from Astra Zeneca. Gretchen Kimmick is on the scientific advisory boards of Boehringer Ingelheim, Eisai, Genomic Health and Agendia. Dr. Kimmick is a consultant for AstraZeneca, Novartis, and Pfizer and has received research funding from Bionovo, PUMA, and Roche.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Susan Dent
    • 1
    Email author
  • Chiara Melloni
    • 2
  • Josee Ivars
    • 3
  • Sarah Sammons
    • 4
  • Gretchen Kimmick
    • 5
  1. 1.Duke Cancer InstituteDuke UniversityDurhamUSA
  2. 2.Duke Clinical Research InstituteDuke University School of MedicineDurhamUSA
  3. 3.Faculty of Health SciencesMcMaster UniversityHamiltonCanada
  4. 4.Duke Cancer InstituteDuke UniversityDurhamUSA
  5. 5.Duke Cancer InstituteDuke UniversityDurhamUSA

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