Hippo/Yap Signaling in Cardiac Development and Regeneration

Regenerative Medicine and Stem-cell Therapy (S M Wu and P Hsieh, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Regenerative Medicine and Stem-cell Therapy

Opinion statement

The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also shown that manipulating the expression of specific genetic pathways can improve the ability of the heart to repair itself. These new insights set the stage for the development of new treatments for heart failure.

Keywords

Hippo/Yap signaling Cardiac development Cardiac regeneration 

Notes

Acknowledgments

J.F.M was supported by the Transatlantic Network of Excellence Award LeDucq Foundation Transatlantic Networks of Excellence in Cardiovascular Research 14CVD01: “Defining the genomic topology of atrial fibrillation,” NIH Grants DE 023177 and HL 118761, and the Vivian L. Smith Foundation (J.F.M.)

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yang Xiao
    • 1
    • 2
  • John Leach
    • 1
  • Jun Wang
    • 1
  • James F. Martin
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Department of Molecular Physiology and BiophysicsBaylor College of MedicineHoustonUSA
  2. 2.Institute of Biosciences and TechnologyTexas A&M Health Science CenterHoustonUSA
  3. 3.Cardiomyocyte Renewal LaboratoryTexas Heart InstituteHoustonUSA
  4. 4.Program in Developmental BiologyBaylor College of MedicineHoustonUSA
  5. 5.Cardiovascular Research InstituteBaylor College of MedicineHoustonUSA

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