Interventional Management of Acute Ischemic Stroke: A Systematic Review

  • J. Scott Pannell
  • David R. Santiago-Dieppa
  • Alexander A. Khalessi
Vascular Disease (R Schainfeld, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Vascular Disease

Opinion statement

Historically, acute ischemic stroke (AIS) trials defined syndromes according to acute clinical presentation and post-ictus parenchymal imaging. With improvements in real-time arterial imaging, modern AIS treatment demands a structural approach based upon the level of cerebrovascular occlusion. The poor concordance of presenting National Institute of Health Stroke Scale (NIHSS) with vessel occlusion in recent trials bespeaks the need for an anatomic perspective. Specifically, patients with large-vessel occlusion (LVO) represent a distinct entity with a poorer prognosis than general AIS patients. Ongoing clinical trials and therapeutic strategies must recognize the varied natural history of AIS patients. Endovascular therapy offers promise in patients with the most severe strokes.


Acute ischemic stroke Large-vessel occlusion CT angiography Intra-arterial stroke therapy Endovascular therapy Retrievable stent 

References and Recommended Reading

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • J. Scott Pannell
    • 1
  • David R. Santiago-Dieppa
    • 1
  • Alexander A. Khalessi
    • 1
  1. 1.Division of NeurosurgeryUniversity of California, San DiegoSan DiegoUSA

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