Cardiac Regeneration in Model Organisms
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Myocardial infarction is the most common cause of cardiac injury in humans and results in acute loss of large numbers of myocardial cells. Unfortunately, the mammalian heart is unable to replenish the cells that are lost following a myocardial infarction and an eventual progression to heart failure can often occur as a result. Regenerative medicine based approaches are actively being developed; however, a complete blueprint on how mammalian hearts can regenerate is still missing. Knowledge gained from studying animal models, such as zebrafish, newt, and neonatal mice, that can naturally regenerate their hearts after injury have provided an understanding of the molecular mechanisms involved in heart repair and regeneration. This research offers novel strategies to overcome the limited regenerative response observed in human patients.
KeywordsCardiac regeneration Model organisms Stem-cell therapy Myocardial infarction Mammalian hearts
This work was done with the support of the California Institute of Regenerative Medicine (TG2-01168), and NIH (NHLBI).
Compliance with Ethics Guidelines
Conflict of Interest
Dr. Laurent Gamba, Dr. Michael Harrison, and Dr. Ching-Ling Lien each declare no potential conflicts of interest relevant to this article.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
References and Recommended Reading
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