Current Urology Reports

, 20:68 | Cite as

Renal Cell Carcinoma: the Oncologist Asks, Can PSMA PET/CT Answer?

  • Chiara PozzessereEmail author
  • Maria Bassanelli
  • Anna Ceribelli
  • Sazan Rasul
  • Shuren Li
  • John O. Prior
  • Francesco Cicone
New Imaging Techniques (S Rais-Bahrami and K Porter, Section Editors)
Part of the following topical collections:
  1. Topical Collection on New Imaging Techniques


Purpose of Review

To critically review the potential clinical applications of prostate-specific membrane antigen (PSMA) radioactive ligands in renal cell carcinoma (RCC).

Recent Findings

Radioactive probes targeting PSMA hold promise in several malignancies in addition to prostate cancer, owing to the expression of PSMA by tumor neovasculature. The majority of clear cell RCCs (ccRCC), the most malignant RCC subtype, express PSMA on tumor-associated neovasculature. The endothelium of less aggressive RCC subtypes is PSMA positive in a lower, but still significant percentage of cases. PSMA might therefore represent an interesting theragnostic target in RCC.


The preliminary data available suggest a potential role for PSMA-targeting radiopharmaceuticals in complementing conventional imaging for staging ccRCC patients at risk of nodal involvement and oligometastatic disease. Additional applications of PSMA imaging may be the selection and the response assessment of patients receiving anti-angiogenic treatments. The effectiveness of PSMA-targeting radionuclide therapy should also be investigated.


Renal cell carcinoma Positron-emission tomography Prostate-specific membrane antigen Diagnostic imaging Response assessment Neoangiogenesis 


Compliance with Ethical Standards

Conflict of Interest

Chiara Pozzessere, Maria Bassanelli, Anna Ceribelli, Sazan Rasul, Shuren Li, John O. Prior, and Francesco Cicone each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Chiara Pozzessere
    • 1
    • 2
    Email author
  • Maria Bassanelli
    • 3
  • Anna Ceribelli
    • 3
  • Sazan Rasul
    • 4
  • Shuren Li
    • 4
  • John O. Prior
    • 2
  • Francesco Cicone
    • 2
  1. 1.Department of RadiologyAUSL Toscana Centro San Giuseppe HospitalEmpoliItaly
  2. 2.Department of Nuclear Medicine and Molecular ImagingLausanne University Hospital and University of LausanneLausanneSwitzerland
  3. 3.Division of Medical OncologySan Camillo De Lellis HospitalRietiItaly
  4. 4.Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided TherapyMedical University of ViennaViennaAustria

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