A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation
Purpose of Review
Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to advances in antibiotic dips targeting the skin flora. To protect against infection, the AMS 700 is pre-coated with InhibiZone (mixture of Rifampin/Minocycline) and the Coloplast Titan, with several antibiotic dip options of differing efficacies. This review discusses strategies to decrease the infection rates in implant surgery, focusing on antibiotic dips.
Current research endorses the use of rifampin/gentamicin as the most studied combination; however, some studies have utilized different dips for additional coverage including the InhibiZone on the AMS 700.
With the increasing prevalence of diabetes and Gram-negative organisms, there is a need to develop strategies for increased coverage against infections. Controlled studies with different antibiotic combinations are needed to identify the ideal cocktail to decrease infection.
KeywordsIPPs (inflatable penile prosthesis) Antibiotic dips Penile implant infections Penile implant surgery
Compliance with Ethical Standards
Conflict of Interest
Soum D. Lokeshwar, Joshua Bitran, and Vinayak Madhusoodanan each declare no potential conflicts of interest.
Bruce Kava is a consultant for Endo and Coloplast.
Ranjith Ramasamy is a consultant for Coloplast, an investigator for Boston Scientific and Direx, and an advisory board member and investigator for Endo and Aytu Biosciences.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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