Current Urology Reports

, 19:69 | Cite as

Is Tamsulosin Linked to Dementia in the Elderly?

  • Jason K. Frankel
  • Yinghui Duan
  • Peter C. AlbertsenEmail author
Benign Prostatic Hyperplasia (K McVary, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Benign Prostatic Hyperplasia


Purpose of Review

Lower urinary tract symptoms (LUTS) result from age-related changes in detrusor function and prostatic growth that are driven by alterations in the ratio of circulating androgens and estrogens. Alpha-adrenergic receptor blockers are commonly used to treat LUTS because they influence urethral tone and intra-urethral pressure. Molecular cloning studies have identified three α1-adrenergic receptor subtypes (α1A, α1B, and α1D). The α1A subtype is predominant in the human prostate but is also present in many parts of the brain that direct cognitive function. Tamsulosin is the most widely used α1-adrenergic receptor antagonist with 12.6 million prescriptions filled in 2010 alone. When compared to the other common types of α1-adrenergic receptor antagonists (i.e., terazosin, doxazosin, and alfuzosin), tamsulosin is 10- to 38-fold more selective for the α1A versus the α1B subtype.

Recent Findings

Duan et al. have recently shown that men taking tamsulosin have a higher risk of developing dementia when compared to men taking other α-adrenergic antagonists or no α-adrenergic antagonists at all (HR 1.17; 95% CI 1.14–1.21).


Based upon this retrospective analysis, we believe that tamsulosin, because of its unique affinity for α1A-adrenergic receptors, may increase the risk of developing dementia when used for an extended period of time. If these findings are confirmed, they carry significant public health implications for an aging society.


Benign prostatic hyperplasia Tamsulosin Dementia Alpha-blockers 


Compliance with Ethical Standards

Conflict of Interest

Jason K. Frankel, Yinghui Duan, and Peter C. Albertsen each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jason K. Frankel
    • 1
  • Yinghui Duan
    • 2
  • Peter C. Albertsen
    • 1
    Email author
  1. 1.Department of SurgeryUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Community Medicine and Health CareUniversity of Connecticut Health CenterFarmingtonUSA

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