Current Urology Reports

, 19:63 | Cite as

Novel Therapy for Male Hypogonadism

  • Robert CarrasquilloEmail author
  • Kevin Chu
  • Ranjith Ramasamy
Andrology and Infertility (L Lipshultz, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Andrology and Infertility


Purpose of Review

Hypogonadism and the treatment of low testosterone is increasingly a subject of medical inquiry and controversy. The few treatments that are FDA-approved such as testosterone topicals, injections, and pellets create significant demand from patients for treatments with more convenient means of administration, fewer adverse effects, and the ability to maintain male fertility. Off-label drugs are in abundant use for low testosterone, including selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors.

Recent Findings

In this review, we summarize the evidence in support of commonly used treatments for male hypogonadism, as well as discuss recent updates in the development of novel therapeutics.


New therapies include nasal testosterone, new oral testosterone formulations, anabolic-androgenic steroids, and selective androgen receptor modulators.


Hypogonadism Testosterone Testosterone replacement therapy SARM Clomiphene 


Compliance with Ethical Standards

Conflict of Interest

Robert Carrasquillo and Kevin Chu each declare no potential conflicts of interest.

Ranjith Ramasamy is the lead investigator on clinical trials for use of Natesto in treatment of hypogonadism with Aytu BioScience ( Identifier NCT03203681).

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as:• Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Robert Carrasquillo
    • 1
    Email author
  • Kevin Chu
    • 1
  • Ranjith Ramasamy
    • 1
  1. 1.Department of UrologyUniversity of Miami Miller School of MedicineMiamiUSA

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