Contemporary Review of Peyronie’s Disease Treatment

  • Edward Capoccia
  • Laurence A. LevineEmail author
Andrology and Infertility (L Lipshultz, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Andrology and Infertility



To analyze the literature on the current treatment options for Peyronie’s disease (PD).

Recent Findings

Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication. Surgery provides the most definitive treatment. The most common adverse effect following surgery is perceived loss of length. Length restoration procedures have recently been developed to address this with promising results reported in small series.


There are a variety of medical treatment options for PD, with CCH getting the most attention for being the first drug to be FDA approved for PD treatment. It is the authors’ opinion that the non-surgical therapy most likely to provide meaningful results is combination therapy utilizing oral, intralesional, and external traction therapy. Surgery remains the gold standard for definitive treatment.


Infertility Andrology Peyronie’s disease Treatment Intracavernosal injection therapy 


Compliance with Ethical Standards

Conflict of Interest

Edward Capoccia declares no potential conflicts of interest.

Laurence A. Levine reports consultant and speaker fees from Boston Scientific and Coloplast.

Human and Animal Rights

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Rush University Medical CenterChicagoUSA

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