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Prostate Biopsy in Active Surveillance Protocols: Immediate Re-biopsy and Timing of Subsequent Biopsies

  • Jonathan H. Wang
  • Tracy M. Downs
  • E. Jason Abel
  • Kyle A. Richards
  • David F. Jarrard
Prostate Cancer (S Prasad, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Prostate Cancer

Abstract

Purpose of Review

This manuscript reviews contemporary literature regarding prostate cancer active surveillance (AS) protocols as well as other tools that may guide the management of biopsy frequency and assess the possibility of progression in low-risk prostate cancer.

Recent Findings

There is no consensus regarding the timing of surveillance biopsies; however, an immediate repeat biopsy within 12 months of diagnosis for patients considering AS confirms patients who have favorable risk disease yet also identifies patients who were undersampled initially. Studies regarding multiparametric MRI, nomograms, and biomarkers show promise in risk stratifying and counseling patients during AS. Further studies are needed to determine if these supplemental tests can decrease the frequency of surveillance biopsies.

Summary

An immediate re-biopsy can help to reduce the risk of missing clinically significant disease. Other clinical tools, including mpMRI, exist that can be used as an adjunct to counsel patients and guide a personalized discussion regarding the frequency of surveillance biopsies.

Keywords

Prostate cancer Active surveillance Prostate biopsy Repeat biopsy Multiparametric MRI 

Notes

Compliance with Ethical Standards

Conflict of Interest

Jonathan H. Wang, Tracy M. Downs, E. Jason Abel, Kyle A. Richards, and David F. Jarrard each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Jonathan H. Wang
    • 1
  • Tracy M. Downs
    • 1
    • 2
  • E. Jason Abel
    • 1
    • 2
  • Kyle A. Richards
    • 1
    • 2
  • David F. Jarrard
    • 1
    • 2
    • 3
  1. 1.Department of UrologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.University of Wisconsin Carbone Comprehensive Cancer CenterMadisonUSA
  3. 3.Environmental and Molecular ToxicologyUniversity of WisconsinMadisonUSA

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