Current Urology Reports

, Volume 11, Issue 6, pp 414–420 | Cite as

New Concepts in the Diagnosis and Treatment of Premature Ejaculation

  • Christopher E. Keel
  • Phillip J. Dorsey
  • William Acker
  • Wayne J. G. HellstromEmail author


Premature ejaculation is the most common male sexual dysfunction. The International Society of Sexual Medicine recently defined premature ejaculation as ejaculation less than about 1 min after penetration, inability to control ejaculation, and resulting negative personal consequences. Evolving treatments target the modulation of the neurobiological causes of the disorder. Current pharmaceuticals focus on aerosolized topical agents, selective serotonin reuptake inhibitors, 5-hydroxytryptamine receptor modulators, and opioid agonists. These emerging medications and the ability to tailor treatments based on genetic information likely will change the paradigm of this disorder and how it will be treated by clinicians.


Premature ejaculation SSRI PSD 502 Neurotomy Nerve ligation Genetic Topical treatment Phosphodiesterase 5 inhibitor 



No potential conflicts of interest related to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Christopher E. Keel
    • 1
  • Phillip J. Dorsey
    • 1
  • William Acker
    • 2
  • Wayne J. G. Hellstrom
    • 1
    Email author
  1. 1.Department of UrologyTulane University Health Sciences CenterNew OrleansUSA
  2. 2.Tulane University Health Sciences CenterNew OrleansUSA

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