Current Urology Reports

, Volume 9, Issue 4, pp 328–332 | Cite as

Prostate cancer and chronic prostatitis

  • Jaspreet S. Sandhu


Prostate cancer and chronic prostatitis are prevalent disorders in men. The cause of prostate cancer and chronic prostatitis is multifocal and diverse. Both disorders exhibit characteristic elevation of serum prostate-specific antigen, currently the primary screening test for prostate cancer. Prostate inflammation, regardless of cause, is the histopathologic hallmark of chronic prostatitis. In general, inflammation is associated with multiple cancers, and prostate inflammation, in particular, is a suggested factor in the development and progression of prostate cancer. This review addresses the link between chronic prostatitis and prostate cancer, especially as it relates to clinical practice.


Prostate Cancer Prostatitis Chronic Prostatitis Chronic Pelvic Pain Syndrome Radical Prostatectomy Specimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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References and Recommended Reading

  1. 1.
    American Cancer Society. Cancer facts and figures, 2006. Available at Accessed May 13, 2008.
  2. 2.
    Penson DF, Chan JM: Prostate Cancer. In Urologic Diseases in America. Edited by Litwin MS, Saigal CS. Washington, DC: US Government Printing Office, 2007. [NIH Publication No. 07-5512:71-122.]Google Scholar
  3. 3.
    DeMarzo AM, Platz EA, Sutcliffe S, et al.: Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007, 7:256–269.CrossRefGoogle Scholar
  4. 4.
    McNaughton-Collins M, Joyce GF, Wise M, Pontari MA: Prostatitis. In Urologic Diseases in America. Edited by Litwin MS, Saigal CS. Washington, DC: US Government Printing Office, 2007. [NIH Publication No. 07-5512:9–42.]Google Scholar
  5. 5.
    Roberts RO, Lieber MM, Bostwick DG, Jacobsen SJ: A review of clinical and pathological prostatitis syndromes. Urology 1997, 49:809–821.PubMedCrossRefGoogle Scholar
  6. 6.
    Roberts RO, Lieber MM, Rhodes T, et al.: Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urology 1998, 51:578–584.PubMedCrossRefGoogle Scholar
  7. 7.
    Dennis LK, Lynch CF, Torner JC: Epidemiologic association between prostatitis and prostate cancer. Urology 2002, 60:78–83.PubMedCrossRefGoogle Scholar
  8. 8.
    Sarma AV, McLaughlin JC, Wallner, et al.: Sexual behavior, sexually transmitted diseases, and prostatitis: the risk of prostate cancer in black men. J Urol 2006, 176:1108–1113.PubMedCrossRefGoogle Scholar
  9. 9.
    Coussens LM, Werb Z: Inflammation and cancer. Nature 2002, 420:860–867.PubMedCrossRefGoogle Scholar
  10. 10.
    Basler JW, Piazza GA: Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. J Urol 2004, 171:S59–S63.PubMedCrossRefGoogle Scholar
  11. 11.
    DeMarzo AM, Marchi VL, Epstein JI, Nelson WG: Proliferative inflammatory atrophy of the prostate. Implications for prostate carcinogenesis. Am J Pathol 1999, 155:1985–1992.Google Scholar
  12. 12.
    Shah R, Mucci NR, Amin A, et al.: Postatrophic hyperplasia of the prostate gland. Neoplastic precursor or innocent bystander? Am J Pathol 2001, 158:1767–1773.PubMedGoogle Scholar
  13. 13.
    Anton RC, Kattan MW, Chakraborty S, Wheeler TM: Postatrophic hyperplasia of the prostate: lack of association with prostate cancer. Am J Surg Pathol 1999, 23:939–936.Google Scholar
  14. 14.
    Gerstenbluth RE, Seftel AD, MacLennan GT, et al.: Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation. J Urol 2002, 167:2267–2270.PubMedCrossRefGoogle Scholar
  15. 15.
    Billis A, Magna LA: Inflammatory atrophy of the prostate. Arch Pathol Lab Med 2003, 127:840–844.PubMedGoogle Scholar
  16. 16.
    MacLennan GT, Eisenberg R, Fleshman RL, et al.: The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006, 176:1012–1016.PubMedCrossRefGoogle Scholar
  17. 17.
    Konig JE, Senge T, Allhoff EP, Konig W: Analysis of the inflammatory network in benign prostate hyperplasia and prostate cancer. Prostate 2004, 58:121–129.PubMedCrossRefGoogle Scholar
  18. 18.
    Zheng SL, Liu W, Wiklund F, et al.: A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Prostate 2006, 66:1556–1564.PubMedCrossRefGoogle Scholar
  19. 19.
    Yoshimura R, Sano H, Masuda C, et al.: Expression of cox-2 in prostate carcinoma. Cancer 2000, 89:589–596.PubMedCrossRefGoogle Scholar
  20. 20.
    National Institutes of Health Summary Statement. National Institute of Health/National Institute of Diabetes and Digestive and Kidney Diseases workshop on chronic prostatitis. Bethesda, MD: December 1995.Google Scholar
  21. 21.
    Nickel JC, Nyberg LM, Hennenfent M: Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology 1999, 54:229–233.PubMedCrossRefGoogle Scholar
  22. 22.
    True LD, Berger RE, Rothman I, et al.: Prostate histopathology and chronic prostatitis/chronic pelvic pain syndrome: a prospective biopsy study. J Urol 1999, 162:2014–2018.PubMedCrossRefGoogle Scholar
  23. 23.
    Carver BS, Bozeman CB, William BJ, Venable DD: The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen. J Urol 2003, 169:589–591.PubMedCrossRefGoogle Scholar
  24. 24.
    Okada K, Kojima M, Naya Y, et al.: Correlation of histological inflammation in needle biopsy specimens with serum prostate-specific antigen levels in men with negative biopsy for prostate cancer. Urology 2000, 55:892–898.PubMedCrossRefGoogle Scholar
  25. 25.
    Stancik I, Luftenegger W, Klimpfinger M, et al.: Effect of NIH-IV prostatitis on free and free-to-total PSA. Eur Urol 2004, 46:760–764.PubMedCrossRefGoogle Scholar
  26. 26.
    Rowe WEJ, Laniado ME, Walker MM, Anup P: Incidental acute prostatic inflammation is associated with a lower percentage of free prostate-specific antigen than other benign conditions of the prostate: a prospective screening study. BJU Int 2006, 97:1039–1042.PubMedCrossRefGoogle Scholar
  27. 27.
    Bozeman CB, Carver BS, Eastham JA, Venable DD: Treatment of chronic prostatitis lowers serum prostate specific antigen. J Urol 2002, 167:1723–1726.PubMedCrossRefGoogle Scholar
  28. 28.
    Nadler RB, Collins MM, Propert KJ, et al.: Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. Urology 2006, 67:337–342.PubMedCrossRefGoogle Scholar
  29. 29.
    Potts JM: Prospective identification of National Institutes of Health category IV prostatitis in men with elevated prostate specific antigen. J Urol 2000, 164:1550–1553.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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