Inflammation and prostate cancer: A focus on infections

Article

Abstract

Despite accumulating evidence that inflammation may affect the development of prostate cancer, responsible causes of intraprostatic inflammation remain elusive. This review presents epidemiologic literature on infections, particularly sexually transmitted and other ascending urogenital infections, as possible causes of intraprostatic inflammation and/or prostate cancer. Study results are interpreted in light of the inflammatory and carcinogenic potential of each infectious agent, as well as the design, analysis, and historical and cultural context of each epidemiologic study. Such findings motivate additional investigation of traditionally explored organisms, such as Neisseria gonorrhoeae, and more recently explored organisms, such as Propionibacterium acnes, with careful consideration of their biology and epidemiology, as well as the design and analysis of epidemiologic studies.

References and Recommended Reading

  1. 1.
    De Marzo AM, Platz EA, Sutcliffe S, et al.: Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007, 7:256–269.PubMedCrossRefGoogle Scholar
  2. 2.
    Lepor H, ed: Prostatic Diseases. Philadelphia: WB Saunders; 2000.Google Scholar
  3. 3.
    Blacklock NJ: Anatomical factors in prostatitis. Br J Urol 1974, 46:47–54.PubMedGoogle Scholar
  4. 4.
    Ravich A, Ravich RA: Prophylaxis of cancer of the prostate, penis, and cervix by circumcision. NY State J Med 1950, 50:1519–1520.Google Scholar
  5. 5.
    Baker LH, Mebust WK, Chin TD, et al.: The relationship of herpesvirus to carcinoma of the prostate. J Urol 1981, 125:370–374.PubMedGoogle Scholar
  6. 6.
    Mandel JS, Schuman LM: Sexual factors and prostatic cancer: results from a case-control study. J Gerontol 1987, 42:259–264.PubMedGoogle Scholar
  7. 7.
    Herbert JT, Birkhoff JD, Feorino PM, Caldwell GG: Herpes simplex virus type 2 and cancer of the prostate. J Urol 1976, 116:611–612.PubMedGoogle Scholar
  8. 8.
    Korodi Z, Wang X, Tedeschi R, et al.: No serological evidence of association between prostate cancer and infection with herpes simplex virus type 2 or human herpesvirus type 8: a nested case-control study. J Infect Dis 2005, 191:2008–2011.PubMedCrossRefGoogle Scholar
  9. 9.
    Sarma AV, McLaughlin JC, Wallner LP, et al.: Sexual behavior, sexually transmitted diseases and prostatitis: the risk of prostate cancer in black men. J Urol 2006, 176:1108–1113.PubMedCrossRefGoogle Scholar
  10. 10.
    Patel DA, Bock CH, Schwartz K, et al.: Sexually transmitted diseases and other urogenital conditions as risk factors for prostate cancer: a case-control study in Wayne County, Michigan. Cancer Causes Control 2005, 16:263–273.PubMedCrossRefGoogle Scholar
  11. 11.
    Rosenblatt KA, Wicklund KG, Stanford JL: Sexual factors and the risk of prostate cancer. Am J Epidemiol 2001, 153:1152–1158.PubMedCrossRefGoogle Scholar
  12. 12.
    Sanford EJ, Geder L, Laychock A, et al.: Evidence for the association of cytomegalovirus with carcinoma of the prostate. J Urol 1977, 118:789–792.PubMedGoogle Scholar
  13. 13.
    Bergh J, Marklund I, Gustavsson C, et al.: No link between viral findings in the prostate and subsequent cancer development. Br J Cancer 2007, 96:137–139.PubMedCrossRefGoogle Scholar
  14. 14.
    Steele R, Lees RE, Kraus AS, Rao C: Sexual factors in the epidemiology of cancer of the prostate. J Chronic Dis 1971, 24:29–37.PubMedCrossRefGoogle Scholar
  15. 15.
    Krain LS: Some epidemiologic variables in prostatic carcinoma in California. Prev Med 1974, 3:154–159.PubMedCrossRefGoogle Scholar
  16. 16.
    Ross RK, Shimizu H, Paganini-Hill A, et al.: Case-control studies of prostate cancer in blacks and whites in southern California. J Natl Cancer Inst 1987, 78:869–874.PubMedGoogle Scholar
  17. 17.
    Lees RE, Steele R, Wardle D: Arsenic, syphilis, and cancer of the prostate. J Epidemiol Community Health 1985, 39:227–230.PubMedCrossRefGoogle Scholar
  18. 18.
    Pelouze PS: Gonorrhea in the Male and Female: A Book for Practitioners. 2nd ed. Philadelphia, PA: WB Saunders; 1935.Google Scholar
  19. 19.
    Wynder EL, Mabuchi K, Whitmore WF Jr: Epidemiology of cancer of the prostate. Cancer 1971, 28:344–360.PubMedCrossRefGoogle Scholar
  20. 20.
    Heshmat MY, Herson J, Kovi J, Niles R: An epidemiologic study of gonorrhea and cancer of the prostate gland. Med Ann Dist Columbia 1973, 42:378–383.PubMedGoogle Scholar
  21. 21.
    Heshmat MY, Kovi J, Herson J, et al.: Epidemiologic association between gonorrhea and prostatic carcinoma. Urology 1975, 6:457–460.PubMedCrossRefGoogle Scholar
  22. 22.
    Niijima T, Koiso K: Incidence of prostatic cancer in Japan and Asia. Scand J Urol Nephrol Suppl 1980, 55:17–21.PubMedGoogle Scholar
  23. 23.
    Mishina T, Watanabe H, Araki H, Nakao M: Epidemiological study of prostatic cancer by matched-pair analysis. Prostate 1985, 6:423–436.PubMedCrossRefGoogle Scholar
  24. 24.
    Danielsson D, Molin L: Demonstration of Neisseria gonorrhoeae in prostatic fluid after treatment of uncomplicated gonorrheal urethritis. Acta Derm Venereol 1971, 51:73–76.PubMedGoogle Scholar
  25. 25.
    Handsfield HH, Lipman TO, Harnisch JP, et al.: Asymptomatic gonorrhea in men. Diagnosis, natural course, prevalence and significance. N Engl J Med 1974, 290:117–123.PubMedGoogle Scholar
  26. 26.
    Pariser H, Farmer AD, Marino AF: Asymptomatic gonorrhea in the male. South Med J 1964, 57:688–690.PubMedGoogle Scholar
  27. 27.
    Sutcliffe S, Zenilman JM, Ghanem KG, et al.: Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration. J Urol 2006, 175:1937–1942.PubMedCrossRefGoogle Scholar
  28. 28.
    Hayes RB, Pottern LM, Strickler H, et al.: Sexual behaviour, STDs and risks for prostate cancer. Br J Cancer 2000, 82:718–725.PubMedCrossRefGoogle Scholar
  29. 29.
    Fernandez L, Galan Y, Jimenez R, et al.: Sexual behaviour, history of sexually transmitted diseases, and the risk of prostate cancer: a case-control study in Cuba. Int J Epidemiol 2005, 34:193–197.PubMedCrossRefGoogle Scholar
  30. 30.
    Oishi K, Okada K, Yoshida O, et al.: A case-control study of prostatic cancer in Kyoto, Japan: sexual risk factors. Prostate 1990, 17:269–279.PubMedCrossRefGoogle Scholar
  31. 31.
    Ilic M, Vlajinac H, Marinkovic J: Case-control study of risk factors for prostate cancer. Br J Cancer 1996, 74:1682–1686.PubMedGoogle Scholar
  32. 32.
    Lightfoot N, Conlon M, Krieger N, et al.: Medical history, sexual, and maturational factors and prostate cancer risk. Ann Epidemiol 2004, 14:655–662.PubMedCrossRefGoogle Scholar
  33. 33.
    Honda GD, Bernstein L, Ross RK, et al.: Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men. Br J Cancer 1988, 57:326–331.PubMedGoogle Scholar
  34. 34.
    Hiatt RA, Armstrong MA, Klatsky AL, Sidney S: Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States). Cancer Causes Control 1994, 5:66–72.PubMedCrossRefGoogle Scholar
  35. 35.
    Hsieh CC, Thanos A, Mitropoulos D, et al.: Risk factors for prostate cancer: a case-control study in Greece. Int J Cancer 1999, 80:699–703.PubMedCrossRefGoogle Scholar
  36. 36.
    Fincham SM, Hill GB, Hanson J, Wijayasinghe C: Epidemiology of prostatic cancer: a case-control study. Prostate 1990, 17:189–206.PubMedCrossRefGoogle Scholar
  37. 37.
    Hayes RB, de Jong FH, Raatgever J, et al.: Physical characteristics and factors related to sexual development and behaviour and the risk for prostatic cancer. Eur J Cancer Prev 1992, 1:239–245.PubMedCrossRefGoogle Scholar
  38. 38.
    Ewings P, Bowie C: A case-control study of cancer of the prostate in Somerset and east Devon. Br J Cancer 1996, 74:661–666.PubMedGoogle Scholar
  39. 39.
    Checkoway H, DiFerdinando G, Hulka BS, Mickey DD: Medical, life-style, and occupational risk factors for prostate cancer. Prostate 1987, 10:79–88.PubMedCrossRefGoogle Scholar
  40. 40.
    Pelucchi C, Talamini R, Negri E, et al.: Genital and urinary tract diseases and prostate cancer risk. Eur J Cancer Prev 2006, 15:254–257.PubMedCrossRefGoogle Scholar
  41. 41.
    Sutcliffe S, Giovannucci E, De Marzo AM, et al.: Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006, 15:2160–2166.PubMedCrossRefGoogle Scholar
  42. 42.
    Dennis LK, Dawson DV: Meta-analysis of measures of sexual activity and prostate cancer. Epidemiology 2002, 13:72–79.PubMedCrossRefGoogle Scholar
  43. 43.
    Sexually Transmitted Diseases. 3rd ed. Edited by Holmes K, Sparling P, Mardh P, et al.: New York, NY: The McGraw-Hill Companies, Inc; 1999.Google Scholar
  44. 44.
    Balis V, Sourvinos G, Soulitzis N, et al.: Prevalence of BK virus and human papillomavirus in human prostate cancer. Int J Biol Markers 2007, 22:245–251.PubMedGoogle Scholar
  45. 45.
    Kuczyk M, Serth J, Machtens S, Jonas U: Detection of viral HPV 16 DNA in prostate cancer and benign prostatic hyperplasia by quantitative PCR-directed analysis. Prostate Cancer Prostatic Dis 2000, 3:S23.PubMedCrossRefGoogle Scholar
  46. 46.
    Strickler HD, Goedert JJ: Sexual behavior and evidence for an infectious cause of prostate cancer. Epidemiol Rev 2001, 23:144–151.PubMedGoogle Scholar
  47. 47.
    Woodworth CD: HPV innate immunity. Front Biosci 2002, 7:2058–2071.CrossRefGoogle Scholar
  48. 48.
    Sutcliffe S, Giovannucci E, Gaydos CA, et al.: Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study. Cancer Epidemiol Biomarkers Prev 2007, 16:1573–1580.PubMedCrossRefGoogle Scholar
  49. 49.
    Sitas F, Urban M, Stein L, et al.: The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population. Infect Agent Cancer 2007, 2:6.PubMedCrossRefGoogle Scholar
  50. 50.
    Montgomery JD, Jacobson LP, Dhir R, Jenkins FJ: Detection of human herpesvirus 8 (HHV-8) in normal prostates. Prostate 2006, 66:1302–1310.PubMedCrossRefGoogle Scholar
  51. 51.
    Jenkins FJ, Hayes RB, Jackson A, et al.: Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects. J Infect Dis 2007, 196:208–211.PubMedCrossRefGoogle Scholar
  52. 52.
    Hoffman LJ, Bunker CH, Pellett PE, et al.: Elevated serop-revalence of human herpesvirus 8 among men with prostate cancer. J Infect Dis 2004, 189:15–20.PubMedCrossRefGoogle Scholar
  53. 53.
    Sutcliffe S, Giovannucci E, Alderete JF, et al.: Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006, 15:939–945.PubMedCrossRefGoogle Scholar
  54. 54.
    Reploeg MD, Storch GA, Clifford DB: BK virus: a clinical review. Clin Infect Dis 2001, 33:191–202.PubMedCrossRefGoogle Scholar
  55. 55.
    Lau SK, Lacey SF, Chen YY, et al.: Low frequency of BK virus in prostatic adenocarcinomas. APMIS 2007, 115:743–749.PubMedCrossRefGoogle Scholar
  56. 56.
    Sfanos KS, Sauvageot J, Fedor HL, et al.: A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. Prostate 2007, 68:306–320.CrossRefGoogle Scholar
  57. 57.
    Das D, Wojno K, Imperiale MJ: BKV as a cofactor in the etiology of prostate cancer in its early stages. J Virol 2008, 82:2705–2714.PubMedCrossRefGoogle Scholar
  58. 58.
    Monini P, Rotola A, Di Luca D, et al.: DNA rearrangements impairing BK virus productive infection in urinary tract tumors. Virology 1995, 214:273–279.PubMedCrossRefGoogle Scholar
  59. 59.
    Newton R, Ribeiro T, Casabonne D, et al.: Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort. Br J Cancer 2005, 93:1305–1306.PubMedCrossRefGoogle Scholar
  60. 60.
    Shah KV, Daniel RW, Stone KR, Elliott AY: Investigation of human urogenital tract tumors of papovavirus etiology: brief communication. J Natl Cancer Inst 1978, 60:579–582.PubMedGoogle Scholar
  61. 61.
    Shannon BA, Cohen RJ, Garrett KL: Polymerase chain reaction-based identification of Propionibacterium acnes types isolated from the male urinary tract: evaluation of adolescents, normal adults and men with prostatic pathology. BJU Int 2006, 98:388–392.PubMedCrossRefGoogle Scholar
  62. 62.
    Cohen RJ, Shannon BA, McNeal JE, et al.: Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution? J Urol 2005, 173:1969–1974.PubMedCrossRefGoogle Scholar
  63. 63.
    Alexeyev O, Bergh J, Marklund I, et al.: Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden). Cancer Causes Control 2006, 17:1127–1133.PubMedCrossRefGoogle Scholar
  64. 64.
    Shannon BA, Cohen RJ, Garrett KL: The antibody response to Propionibacterium acnes is an independent predictor of serum prostate-specific antigen levels in biopsy-negative men. BJU Int 2008, 101:429–435.PubMedGoogle Scholar
  65. 65.
    Sutcliffe S, Giovannucci E, Isaacs WB, et al.: Acne and risk of prostate cancer. Int J Cancer 2007, 121:2688–2692.PubMedCrossRefGoogle Scholar
  66. 66.
    Daniels NA, Ewing SK, Zmuda JM, et al.: Correlates and prevalence of prostatitis in a large community-based cohort of older men. Urology 2005, 66:964–970.PubMedCrossRefGoogle Scholar
  67. 67.
    Wei Q, Tang X, Yang Y, et al.: Risk factors of prostate cancer—a matched case-control study [in Chinese]. Hua Xi Yi Ke Da Xue Xue Bao 1994, 25:87–90.PubMedGoogle Scholar
  68. 68.
    Ross RK, Paganini-Hill A, Henderson BE: The etiology of prostate cancer: what does the epidemiology suggest? Prostate 1983, 4:333–344.PubMedCrossRefGoogle Scholar
  69. 69.
    Nakata S, Imai K, Yamanaka H: Study of risk factors for prostatic cancer [in Japanese]. Hinyokika Kiyo 1993, 39:1017–1024; discussion 24–25.PubMedGoogle Scholar
  70. 70.
    Roberts RO, Bergstralh EJ, Bass SE, et al.: Prostatitis as a risk factor for prostate cancer. Epidemiology 2004, 15:93–99.PubMedCrossRefGoogle Scholar
  71. 71.
    Rothman I, Stanford JL, Kuniyuki A, Berger RE: Self-report of prostatitis and its risk factors in a random sample of middle-aged men. Urology 2004, 64:876–879; discussion 879–80.PubMedCrossRefGoogle Scholar
  72. 72.
    Zhu K, Stanford JL, Daling JR, et al.: Vasectomy and prostate cancer: a case-control study in a health maintenance organization. Am J Epidemiol 1996, 144:717–722.PubMedGoogle Scholar
  73. 73.
    Krieger JN, Nyberg L, Nickel JC: NIH consensus definition and classification of prostatitis. JAMA 1999, 281:236–237.CrossRefGoogle Scholar
  74. 74.
    Schaeffer AJ, Knauss JS, Landis JR, et al.: Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort Study. J Urol 2002, 168:1048–1053.PubMedCrossRefGoogle Scholar
  75. 75.
    Carver BS, Bozeman CB, Williams BJ, Venable DD: The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen. J Urol 2003, 169:589–591.PubMedCrossRefGoogle Scholar
  76. 76.
    MacLennan GT, Eisenberg R, Fleshman RL, et al.: The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol 2006, 176:1012–1016.PubMedCrossRefGoogle Scholar
  77. 77.
    Urisman A, Molinaro RJ, Fischer N, et al.: Identification of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog 2006, 2:e25.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Alvin J. Siteman Cancer Center and the Department of SurgeryWashington University School of MedicineSt. LouisUSA

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