Current Urology Reports

, Volume 8, Issue 3, pp 185–189 | Cite as

Testosterone replacement therapy and prostate cancer: A word of caution

  • Timothy C. Brand
  • Edith Canby-Hagino
  • Ian M. Thompson
Article

Abstract

The number of men for whom testosterone is prescribed is rapidly increasing. The aging man normally demonstrates a gradual decline in testosterone. Symptoms of hypogonadism include erectile dysfunction, diminished libido, sarcopenia, increased adiposity, osteopenia and osteoporosis, impaired cognition, and depression. There is a paucity of data regarding both efficacy and safety of testosterone replacement therapy. Testosterone levels have been shown to modulate prostate cancer risk and progression. A prospective evaluation of prostate cancer risk with testosterone replacement therapy has not been conducted. We outline concerns and recommendations for the use of testosterone replacement therapy in the aging man.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Timothy C. Brand
    • 1
  • Edith Canby-Hagino
  • Ian M. Thompson
  1. 1.Department of UrologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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