Current Urology Reports

, Volume 5, Issue 4, pp 274–279

The role of 5-α-reductase inhibition as monotherapy in view of the MTOPS data

  • Jaspreet S. Sandhu
  • Alexis E. Te


Medical treatment for the symptoms of benign prostatic hyperplasia (BPH) consists of α blockers and 5-α-reductase inhibitors. Data suggest that 5-α-reductase inhibitors can prevent progression of BPH and reduce the risk of BPH-related surgery, especially in men with large-volume prostates. Results from the largest randomized, prospective, placebo-controlled trial, the Medical Therapy of Prostatic Symptoms trial, have been presented. These results support the notion of using 5-α-reductase inhibitors for the prevention of BPH progression and BPH-related surgery. Furthermore, long-term 5-α-reductase inhibitor monotherapy, although slow in onset, is a viable therapy for symptom relief in men with mild to moderate symptoms.


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Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Jaspreet S. Sandhu
    • 1
  • Alexis E. Te
    • 1
  1. 1.Brady Prostate Center, Department of UrologyNew York Presbyterian HospitalNew YorkUSA

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