Current Urology Reports

, Volume 4, Issue 6, pp 466–471 | Cite as

Erectile dysfunction in the cardiac patient

  • Robert A. Kloner


Erectile dysfunction (ED) often is caused by endothelial dysfunction and may be a sign that a patient has vascular disease elsewhere in the body. Risk factors for coronary artery disease such as lipid abnormalities, smoking, diabetes, and hypertension also are risk factors for ED. Oral therapy for ED, such as sildenafil, inhibits phosphodiesterase-5 (PDE-5) and the breakdown of cyclic guanosine monophosphate. PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain contraindicated in patients receiving organic nitrates. These agents are mild vasodilators and are being investigated for their treatment potential for patients with pulmonary hypertension, heart failure, and endothelial dysfunction.


Erectile Dysfunction Brachial Artery Tadalafil Iloprost Vardenafil 
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Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Robert A. Kloner
    • 1
  1. 1.Heart InstituteGood Samaritan HospitalLos AngelesUSA

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