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A Review of Genome Wide Association Studies for Erectile Dysfunction

  • Darshan P. Patel
  • Alexander W. Pastuszak
  • James M. HotalingEmail author
Female Sexual Dysfunction and Disorders (A Pastuszak and N Thirumavalavan, Section Editors)
  • 4 Downloads
Part of the following topical collections:
  1. Topical Collection on Female Sexual Dysfunction and Disorders

Abstract

Purpose of Review

To review large cohort genome wide association studies for erectile dysfunction.

Recent Findings

Two recent genome wide association studies using the Genetic Epidemiology Research in Adult Health and Aging cohort, UK Biobank, and the Partners HealthCare Biobank have identified an association between unique single nucleotide polymorphisms involved in the regulatory activity of single-minded homolog 1 (SIM1) and risk of erectile dysfunction. SIM1 is involved in the leptin-melanocortin pathway and may contribute to centrally mediated erectile dysfunction.

Summary

Identification of novel loci associated with erectile function from genome wide association studies will help expand the understanding of the breadth of pathways that contribute to erectile dysfunction. This will help accelerate studies of novel therapies for the treatment of erectile dysfunction.

Keywords

Erectile dysfunction Sexual dysfunction, physiological Genome-wide association study Genetic therapy SIM1 protein, human 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Patel has nothing to disclosure regarding the material discussed in this article.

Dr. Pastuszak reports his associations with Endo Pharmaceuticals – advisor, speaker, consultant, research and fellowship support; Antares Pharmaceuticals – advisor; and Woven Health – founder and leadership position.

Dr. Hotaling reports associations with Endo Pharmaceuticals – research and fellowship grant; Boston Scientific – fellowship grant; Nanonc, StreamDx, Andro360 – leadership position/founder.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Darshan P. Patel
    • 1
  • Alexander W. Pastuszak
    • 1
  • James M. Hotaling
    • 1
    Email author
  1. 1.Division of Urology, Department of SurgeryUniversity of Utah Health, University of Utah School of MedicineSalt Lake CityUSA

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