Testosterone and Physical Function
Purpose of Review
The purpose of this review is to provide an overview of recent data on the relationship of testosterone with physical function.
The safety of testosterone treatment in older men who do not have hypogonadism has increasingly been questioned. In recent years, multiple studies have been performed to better understand the relationship between testosterone and physical function.
Overall, the relationship between testosterone and physical function is unclear. Endogenous and exogenous testosterones are associated with favorable changes in body composition and, to a lesser extent, muscle strength. However, the relationship between testosterone and physical function is less clear in healthy older men. Exogenous testosterone is associated with favorable changes in body composition and strength, but further data are needed to understand if treatment is associated with functional improvements and ultimately decreased disability and morbidity.
KeywordsTestosterone Androgens Sex hormones Physical function, aging Body composition Strength
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published within the last three years, have been highlighted as: • Of importance •• Of major importance
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