Adjunct Management of Male Hypogonadism
While testosterone replacement therapy (TRT) has been the main strategy in the management of male hypogonadism, the significant risks associated with TRT have driven the search for alternative strategies to treat hypogonadism. With the high preponderance of secondary and mixed-dysfunction hypogonadism, medications such as clomiphene citrate, aromatase inhibitors, and human chorionic gonadotropin (HCG), which target the hypothalamus/pituitary portions of the hypothalamus-pituitary-gonadal axis, have increasingly been studied despite not being FDA-approved for treatment of male hypogonadism. While these agents have demonstrated some promise in managing male hypogonadism, the current evidence behind their use remains weak and there is a need for well-designed, prospective trials that can further elucidate the roles for these agents in the management of male hypogonadism.
KeywordsHypogonadism Clomiphene citrate Aromatase inhibitor Human chorionic gonadotropin (HCG) Testosterone
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Conflicts of Interest
The authors declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
PVB and BBN were supported by The Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust.
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