The Role of ANK in Calcium Pyrophosphate Deposition Disease

  • Elizabeth Mitton-Fitzgerald
  • Claudia M. GohrEmail author
  • Brittany Bettendorf
  • Ann K. Rosenthal
Crystal Arthritis (MH Pillinger and SK Samuels, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Crystal Arthritis


The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease.


ANK ANKH Progressive ankylosis gene Calcium pyrophosphate Pseudogout Chondrocalcinosis 


Compliance with Ethical Standards

Conflict of Interest

EMF, CMG, BB, and AKR declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Elizabeth Mitton-Fitzgerald
    • 1
  • Claudia M. Gohr
    • 1
    Email author
  • Brittany Bettendorf
    • 1
  • Ann K. Rosenthal
    • 1
  1. 1.The Division of Rheumatology, Department of MedicineMedical College of Wisconsin and the Zablocki VA Medical CenterMilwaukeeUSA

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