The Prediction and Monitoring of Toxicity Associated with Long-Term Systemic Glucocorticoid Therapy

  • Emma Harris
  • Ana Tiganescu
  • Sandy Tubeuf
  • Sarah Louise Mackie
Health Economics and Quality of Life (M Harrison, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Health Economics and Quality of Life

Abstract

Glucocorticoids are often required for adequate control of inflammation in many serious inflammatory diseases; common indications for long-term treatment include polymyalgia rheumatica, giant cell arteritis, asthma and chronic obstructive pulmonary disease. Long-term glucocorticoid therapy is, however, associated with many adverse effects involving skin, gastro-intestinal, eye, skeletal muscle, bone, adrenal, cardio-metabolic and neuropsychiatric systems. This balance between benefits and risks of glucocorticoids is important for clinical practice and glucocorticoid-related adverse effects can significantly impair health-related quality of life. Understanding the nature and mechanisms of glucocorticoid-related adverse effects may inform how patients are monitored for toxicity and identify those groups, such as older people, that may need closer monitoring. For clinical trials in diseases commonly treated with glucocorticoids, standardised measurement of glucocorticoid-related adverse effects would facilitate future evidence synthesis and meta-analysis.

Keywords

Glucocorticoids Adverse effects Giant cell arteritis Polymyalgia rheumatica 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Emma Harris, Ana Tiganescu, Sandy Tubeuf and Sarah Louise Mackie declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Emma Harris
    • 1
  • Ana Tiganescu
    • 1
  • Sandy Tubeuf
    • 2
  • Sarah Louise Mackie
    • 3
  1. 1.Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James’s University HospitalUniversity of LeedsLeedsUK
  2. 2.Leeds Institute of Health SciencesUniversity of LeedsLeedsUK
  3. 3.Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton HospitalUniversity of Leeds and the Leeds Teaching Hospitals NHS TrustLeedsUK

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