Kawasaki Disease: Pathophysiology, Clinical Manifestations, and Management

  • Victoria R. Dimitriades
  • Amanda G. Brown
  • Abraham Gedalia
VASCULITIS (LR ESPINOZA, SECTION EDITOR)

DOI: 10.1007/s11926-014-0423-x

Cite this article as:
Dimitriades, V.R., Brown, A.G. & Gedalia, A. Curr Rheumatol Rep (2014) 16: 423. doi:10.1007/s11926-014-0423-x
Part of the following topical collections:
  1. Topical Collection on Vasculitis

Abstract

Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.

Keywords

Kawasaki disease Coronary artery Aneurysm Vasculitis Immunoglobulin Corticosteroids IVIg resistance Pathophysiology Clinical manifestations Management Treatment Etiology Diagnosis 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Victoria R. Dimitriades
    • 1
  • Amanda G. Brown
    • 1
  • Abraham Gedalia
    • 1
    • 2
  1. 1.Division of Pediatric Rheumatology, Departments of PediatricsLSU Health Sciences Center and Children’s HospitalNew OrleansUSA
  2. 2.Department of Pediatrics/RheumatologyChildren’s HospitalNew OrleansUSA

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