Current Rheumatology Reports

, 16:403

Pregnancy Morbidity in Antiphospholipid Syndrome: What Is the Impact of Treatment?

  • Guilherme R. de Jesús
  • Gustavo Rodrigues
  • Nilson R. de Jesús
  • Roger A. Levy
Part of the following topical collections:
  1. Topical Collection on Antiphospholipid Syndrome


Women with persistently circulating antiphospholipid antibodies (aPL) have a higher incidence of recurrent abortions, fetal losses, pre-eclampsia, and placental insufficiency. Current treatment of patients with antiphospholipid syndrome (APS) during pregnancy with heparin and aspirin can act by preventing clot formation and improving live birth rates, but other obstetric morbidities remain high, especially in patients with a history of thrombotic events. In addition to the classical thrombotic placental events, other factors involving inflammation and complement activation seem to play a role in certain complications. In this article, we will review how medications interfere in the pathogenic mechanisms of APS, discuss the impact of current recommended treatment on pregnancy morbidity, and analyze new promising therapies.


Antiphospholipid syndrome APS Obstetric APS Obstetric antiphospholipid syndrome Pre-eclampsia Intrauterine growth restriction Prematurity Treatment Abortion Pregnancy loss Fetal death Heparin Aspirin Complement activation Thrombosis Hydroxychloroquine Eculizumab 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Guilherme R. de Jesús
    • 1
    • 4
  • Gustavo Rodrigues
    • 1
    • 5
  • Nilson R. de Jesús
    • 1
    • 6
  • Roger A. Levy
    • 2
    • 3
    • 7
  1. 1.Department of Obstetrics, Faculdade de Ciências MédicasUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil
  2. 2.Department of Rheumatology, Faculdade de Ciências MédicasUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil
  3. 3.Federico FoundationVaduzLiechtenstein
  4. 4.Rio de JaneiroBrazil
  5. 5.RecreioBrazil
  6. 6.Rio de JaneiroBrazil
  7. 7.Rio de JaneiroBrazil

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