Duration of Anticoagulation Treatment for Thrombosis in APS: Is It Ever Safe to Stop?

Part of the following topical collections:
  1. Topical Collection on Antiphospholipid Syndrome


Antiphospholipid syndrome (APS) is an auto-immune thrombophilia for which anti-thrombotic medication is necessary for long-term management to reduce thrombotic risk or pregnancy morbidity. Choosing the type of pharmacological treatment, i.e. the intensity and duration of anticoagulation, depends on the severity of an individual’s APS and the risk of bleeding. This article reviews the current literature on anticoagulation therapy, provides recommendations on when to initiate therapy, and suggests possible alternatives for optimisation of management.


Antiphospholipid syndrome (APS) Antiphospholipid (aPL) Systemic lupus erythematosus (SLE) Anticoagulation therapy Intensity Duration Thromboprophylaxis Refractory APS Thrombosis 


Conflict of Interest

Sinthiya Punnialingam declares that she has no conflict of interest.

Munther A. Khamashta declares that he has no conflict of interest.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of General MedicineGuy’s and St Thomas’ HospitalLondonUK
  2. 2.Graham Hughes Lupus Research Laboratory, Rayne InstituteSt Thomas’ HospitalLondonUK

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