Current Rheumatology Reports

, Volume 14, Issue 4, pp 364–368

What Have Genome-Wide Studies Told Us About Psoriatic Arthritis?

PSORIATIC ARTHRITIS (O FITZGERALD AND P HELLIWELL, SECTION EDITORS)

DOI: 10.1007/s11926-012-0255-5

Cite this article as:
Bluett, J. & Barton, A. Curr Rheumatol Rep (2012) 14: 364. doi:10.1007/s11926-012-0255-5

Abstract

There is convincing evidence to suggest a strong genetic component to psoriatic arthritis (PsA), with studies reporting a 40-fold risk to first-degree relatives of patients with disease. However, compared with rheumatoid arthritis, our understanding of the genetic etiology of PsA is less well-developed. Only three modestly sized genome-wide association studies of PsA have been undertaken to date, but they have identified the HLA-C region, IL12B, TRAF3IP2, and FBXL19 genes as being associated with PsA susceptibility. Results of genome-wide association studies of psoriasis and rheumatoid arthritis have been used to identify candidate genes for subsequent testing in PsA and have led to the identification of additional susceptibility factors for PsA. Most show overlap with psoriasis, whereas the overlap with rheumatoid arthritis is less pronounced. However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus.

Keywords

Genome-wide association study GWAS Psoriasis Psoriatic arthritis Genetics IL-13 TRAF3IP2 Rheumatoid arthritis Single nucleotide polymorphism 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Arthritis Research UK Epidemiology Unit, Stopford Building, University of ManchesterManchesterUK
  2. 2.Arthritis Research UK Epidemiology Unit, University of Manchester, Arthritis Research UK Epidemiology Unit and Kellgren Centre for Rheumatology, Manchester Academy of Health Sciences, University of Manchester and Manchester Royal InfirmaryManchesterUK

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